Tissue uptake of BSH in patients with glioblastoma in the EORTC 11961 phase I BNCT trial

Katalin Hideghéty, Wolfgang Sauerwein, Andrea Wittig, Claudia Götz, Philippe Paquis, Frank Grochulla, Klaus Haselsberger, John Wolbers, Ray Moss, Rene Huiskamp, Heinz Frankhauser, Martin De Vries, Detlef Gabel

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Abstract

Purpose: The uptake of the boron compound Na2B12H10-SH (BSH) in tumor and normal tissues was investigated in the frame of the EORTC phase I trial 'Postoperative treatment of glioblastoma with BNCT at the Petten Irradiation Facility' (protocol 11961). Methods and materials: The boron concentration in blood, tumor, normal brain, dura, muscle, skin and bone was detected using inductively coupled plasma-atomic emission spectroscopy in 13 evaluable patients. In a first group of 10 patients 100 mg BSH/kg bodyweight (BW) were administered; a second group of 3 patients received 22.9 mg BSH/kg BW. The toxicity due to BSH was evaluated. Results: The average boron concentration in the tumor was 19.9 ± 9.1 ppm (1 standard deviation (SD)) in the high dose group and 9.8 ± 3.3 ppm in the low dose group, the tumor/blood ratios were 0.6 ± 0.2 and 0.9 ± 0.2, respectively. The highest boron uptake has been detected in the dura, very low uptake was found in the bone, the cerebro-spinal fluid and especially in the brain (brain/blood ratio 0.2 ± 0.02 and 0.4 ± 0.2). No toxicity was detected except flush-like symptoms in 2 cases during a BSH infusion at a much higher speed than prescribed. Conclusion: BSH proved to be safe for clinical application at a dose of 100 mg BSH/kg infused and at a dose rate of 1 mg/kg/min. The study underlines the importance of a further investigation of BSH uptake in order to obtain enough data for significant statistical analysis. The boron concentration in blood seems to be a quite reliable parameter to predict the boron concentration in other tissues.

Original languageEnglish
Pages (from-to)145-156
Number of pages12
JournalJournal of Neuro-Oncology
Volume62
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • BNCT
  • BSH tissue uptake
  • BSH toxicity
  • Glioblastoma

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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  • Cite this

    Hideghéty, K., Sauerwein, W., Wittig, A., Götz, C., Paquis, P., Grochulla, F., Haselsberger, K., Wolbers, J., Moss, R., Huiskamp, R., Frankhauser, H., De Vries, M., & Gabel, D. (2003). Tissue uptake of BSH in patients with glioblastoma in the EORTC 11961 phase I BNCT trial. Journal of Neuro-Oncology, 62(1), 145-156. https://doi.org/10.1023/A:1023201308434