"Tissue" transglutaminase in AIDS

Alessandra Amendola, L. Fésüs, Mauro Piacentini, Z. Szondy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Apoptosis or programmed cell death (PCD) is an active process of cellular self-destruction, essential for embryonic development and maintenance of homeostasis of multicellular organisms. Programmed cell death induction can serve as a defence mechanism of the host against intracellular microbes. Virus infections trigger host cell apoptosis, which can either limit virus production or contribute directly to viral pathogenesis. Several independent laboratories have identified "tissue" transglutaminase (tTG) as a potentially important player of the cell death program(s). This gene is specifically expressed in cells dying during mammalian development as well as in those undergoing apoptosis in various patho-physiological and experimental settings [Eur. J. Cell Biol. 56 (1991) 170; Piacentini, M., Davies, P.J.A., Fesus, L., 1994. Tissue transglutaminase in cells undergoing apoptosis. In: Tomei, L.D., Cope, F.O. (Eds.), Apoptosis II: The molecular basis of apoptosis in disease. Cold Spring Harbor Lab. Press, pp. 143-165.]. This chapter reviews recent studies concerning the expression and the possible role of "tissue" transglutaminase (tTG) in apoptotic cells; particular emphasis is given to its expression in the cell death pathways associated with HIV infection in the immune system. We propose here that the induction of the tTG gene in cells of the immune system, as well as the detection of the isodipeptide ε(γ-glutamyl)lysine in plasma, are useful markers of apoptosis and might make it possible to monitor disease progression in HIV-infected individuals.

Original languageEnglish
Pages (from-to)145-159
Number of pages15
JournalJournal of Immunological Methods
Volume265
Issue number1-2
DOIs
Publication statusPublished - Jul 1 2002

Fingerprint

Acquired Immunodeficiency Syndrome
Apoptosis
Cell Death
Immune System
Virus Diseases
transglutaminase 2
Genes
Lysine
HIV Infections
Embryonic Development
Disease Progression
Homeostasis
Maintenance
HIV
Viruses

Keywords

  • ε(γ-glutamyl)lysine
  • Activation-induced cell death
  • Apoptosis
  • Bcl-2
  • EIF5A
  • HIV-infection
  • Protein cross-links
  • Tissue transglutaminase

ASJC Scopus subject areas

  • Biotechnology
  • Immunology

Cite this

"Tissue" transglutaminase in AIDS. / Amendola, Alessandra; Fésüs, L.; Piacentini, Mauro; Szondy, Z.

In: Journal of Immunological Methods, Vol. 265, No. 1-2, 01.07.2002, p. 145-159.

Research output: Contribution to journalArticle

Amendola, Alessandra ; Fésüs, L. ; Piacentini, Mauro ; Szondy, Z. / "Tissue" transglutaminase in AIDS. In: Journal of Immunological Methods. 2002 ; Vol. 265, No. 1-2. pp. 145-159.
@article{3e35d1ed48544db58a84b3bffdb0b75a,
title = "{"}Tissue{"} transglutaminase in AIDS",
abstract = "Apoptosis or programmed cell death (PCD) is an active process of cellular self-destruction, essential for embryonic development and maintenance of homeostasis of multicellular organisms. Programmed cell death induction can serve as a defence mechanism of the host against intracellular microbes. Virus infections trigger host cell apoptosis, which can either limit virus production or contribute directly to viral pathogenesis. Several independent laboratories have identified {"}tissue{"} transglutaminase (tTG) as a potentially important player of the cell death program(s). This gene is specifically expressed in cells dying during mammalian development as well as in those undergoing apoptosis in various patho-physiological and experimental settings [Eur. J. Cell Biol. 56 (1991) 170; Piacentini, M., Davies, P.J.A., Fesus, L., 1994. Tissue transglutaminase in cells undergoing apoptosis. In: Tomei, L.D., Cope, F.O. (Eds.), Apoptosis II: The molecular basis of apoptosis in disease. Cold Spring Harbor Lab. Press, pp. 143-165.]. This chapter reviews recent studies concerning the expression and the possible role of {"}tissue{"} transglutaminase (tTG) in apoptotic cells; particular emphasis is given to its expression in the cell death pathways associated with HIV infection in the immune system. We propose here that the induction of the tTG gene in cells of the immune system, as well as the detection of the isodipeptide ε(γ-glutamyl)lysine in plasma, are useful markers of apoptosis and might make it possible to monitor disease progression in HIV-infected individuals.",
keywords = "ε(γ-glutamyl)lysine, Activation-induced cell death, Apoptosis, Bcl-2, EIF5A, HIV-infection, Protein cross-links, Tissue transglutaminase",
author = "Alessandra Amendola and L. F{\'e}s{\"u}s and Mauro Piacentini and Z. Szondy",
year = "2002",
month = "7",
day = "1",
doi = "10.1016/S0022-1759(02)00077-7",
language = "English",
volume = "265",
pages = "145--159",
journal = "Journal of Immunological Methods",
issn = "0022-1759",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - "Tissue" transglutaminase in AIDS

AU - Amendola, Alessandra

AU - Fésüs, L.

AU - Piacentini, Mauro

AU - Szondy, Z.

PY - 2002/7/1

Y1 - 2002/7/1

N2 - Apoptosis or programmed cell death (PCD) is an active process of cellular self-destruction, essential for embryonic development and maintenance of homeostasis of multicellular organisms. Programmed cell death induction can serve as a defence mechanism of the host against intracellular microbes. Virus infections trigger host cell apoptosis, which can either limit virus production or contribute directly to viral pathogenesis. Several independent laboratories have identified "tissue" transglutaminase (tTG) as a potentially important player of the cell death program(s). This gene is specifically expressed in cells dying during mammalian development as well as in those undergoing apoptosis in various patho-physiological and experimental settings [Eur. J. Cell Biol. 56 (1991) 170; Piacentini, M., Davies, P.J.A., Fesus, L., 1994. Tissue transglutaminase in cells undergoing apoptosis. In: Tomei, L.D., Cope, F.O. (Eds.), Apoptosis II: The molecular basis of apoptosis in disease. Cold Spring Harbor Lab. Press, pp. 143-165.]. This chapter reviews recent studies concerning the expression and the possible role of "tissue" transglutaminase (tTG) in apoptotic cells; particular emphasis is given to its expression in the cell death pathways associated with HIV infection in the immune system. We propose here that the induction of the tTG gene in cells of the immune system, as well as the detection of the isodipeptide ε(γ-glutamyl)lysine in plasma, are useful markers of apoptosis and might make it possible to monitor disease progression in HIV-infected individuals.

AB - Apoptosis or programmed cell death (PCD) is an active process of cellular self-destruction, essential for embryonic development and maintenance of homeostasis of multicellular organisms. Programmed cell death induction can serve as a defence mechanism of the host against intracellular microbes. Virus infections trigger host cell apoptosis, which can either limit virus production or contribute directly to viral pathogenesis. Several independent laboratories have identified "tissue" transglutaminase (tTG) as a potentially important player of the cell death program(s). This gene is specifically expressed in cells dying during mammalian development as well as in those undergoing apoptosis in various patho-physiological and experimental settings [Eur. J. Cell Biol. 56 (1991) 170; Piacentini, M., Davies, P.J.A., Fesus, L., 1994. Tissue transglutaminase in cells undergoing apoptosis. In: Tomei, L.D., Cope, F.O. (Eds.), Apoptosis II: The molecular basis of apoptosis in disease. Cold Spring Harbor Lab. Press, pp. 143-165.]. This chapter reviews recent studies concerning the expression and the possible role of "tissue" transglutaminase (tTG) in apoptotic cells; particular emphasis is given to its expression in the cell death pathways associated with HIV infection in the immune system. We propose here that the induction of the tTG gene in cells of the immune system, as well as the detection of the isodipeptide ε(γ-glutamyl)lysine in plasma, are useful markers of apoptosis and might make it possible to monitor disease progression in HIV-infected individuals.

KW - ε(γ-glutamyl)lysine

KW - Activation-induced cell death

KW - Apoptosis

KW - Bcl-2

KW - EIF5A

KW - HIV-infection

KW - Protein cross-links

KW - Tissue transglutaminase

UR - http://www.scopus.com/inward/record.url?scp=0036644018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036644018&partnerID=8YFLogxK

U2 - 10.1016/S0022-1759(02)00077-7

DO - 10.1016/S0022-1759(02)00077-7

M3 - Article

C2 - 12072185

AN - SCOPUS:0036644018

VL - 265

SP - 145

EP - 159

JO - Journal of Immunological Methods

JF - Journal of Immunological Methods

SN - 0022-1759

IS - 1-2

ER -