Tissue-specific homing of immune cells in malignant skin tumors

Hajnalka Jókai, Márta Marschalkó, Judit Csomor, József Szakonyi, Orsolya Kontár, G. Barna, S. Kárpáti, Péter Holló

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Tissue-specific migration of immune cells involved both in physiological and pathological immune responses is a current research subject for medical science. Several homing molecules have been identified orchestrating extravasation of immune cells to certain peripheral nonlymphoid tissues such as gut, lung and skin. Regarding lymphocyte homing to skin, the first-line defense of human body cutaneous lymphocyte associated antigen (CLA) and a group of chemokine-chemokine receptor pairs are considered to be of crucial importance. The aim of the present review is to summarize existing knowledge about skin- and tumor-specific migration of immune cells playing a major pathogenetic role in host immune responses induced by nonlymphoid malignant skin tumors as well as in the development of primary cutaneous T-cell lymphomas (CTCL). Melanoma malignum, squamous and basal cell carcinoma evoke host immune responses and consequently a subset of reactive immune cells is recruited to site of the tumor. Regarding migratory process and exact functional role of these cells a growing number of data is available in literature. On the other hand tissue-specific immune cell homing is regarded as a key process in the pathogenesis of CTCL where malignant T-lymphocytes can be found in circulation and symptomatic skin. Hereby homing mechanism of malignant T-cells in mycosis fungoides and Sézary-syndrome as separate clinical entities of CTCL is discussed. A precise insight into the molecular background of skin- and tumor-specific immune cell migration can contribute to developing efficient vaccine therapies in non-lymphoid malignant skin tumors and beneficial treatment modalities in CTCL.

Original languageEnglish
Pages (from-to)749-759
Number of pages11
JournalPathology and Oncology Research
Volume18
Issue number4
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Cutaneous T-Cell Lymphoma
Skin
Neoplasms
Cell Movement
Lymphocytes
Research Subjects
T-Lymphocytes
Active Immunotherapy
Mycosis Fungoides
Chemokine Receptors
Basal Cell Carcinoma
Human Body
Chemokines
Squamous Cell Carcinoma
Melanoma
Antigens
Lung
Therapeutics

Keywords

  • Basal cell carcinoma
  • Cutaneous lymphocyte associated antigen
  • Cutaneous T-cell lymphoma
  • Lymphocyte homing receptors
  • Malignant melanoma
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Jókai, H., Marschalkó, M., Csomor, J., Szakonyi, J., Kontár, O., Barna, G., ... Holló, P. (2012). Tissue-specific homing of immune cells in malignant skin tumors. Pathology and Oncology Research, 18(4), 749-759. https://doi.org/10.1007/s12253-012-9529-5

Tissue-specific homing of immune cells in malignant skin tumors. / Jókai, Hajnalka; Marschalkó, Márta; Csomor, Judit; Szakonyi, József; Kontár, Orsolya; Barna, G.; Kárpáti, S.; Holló, Péter.

In: Pathology and Oncology Research, Vol. 18, No. 4, 10.2012, p. 749-759.

Research output: Contribution to journalArticle

Jókai, H, Marschalkó, M, Csomor, J, Szakonyi, J, Kontár, O, Barna, G, Kárpáti, S & Holló, P 2012, 'Tissue-specific homing of immune cells in malignant skin tumors', Pathology and Oncology Research, vol. 18, no. 4, pp. 749-759. https://doi.org/10.1007/s12253-012-9529-5
Jókai, Hajnalka ; Marschalkó, Márta ; Csomor, Judit ; Szakonyi, József ; Kontár, Orsolya ; Barna, G. ; Kárpáti, S. ; Holló, Péter. / Tissue-specific homing of immune cells in malignant skin tumors. In: Pathology and Oncology Research. 2012 ; Vol. 18, No. 4. pp. 749-759.
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