Tissue specific expression of the acetylcholinesterase gene in Drosophila melanogaster

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Abstract

Acetylcholinesterase (AChE) is mainly membrane bound in the central nervous system (CNS) of larvae and in the head and thorax of adults of Drosophila melanogaster; it is mostly soluble in the larval carcass, the adult abdomen, similar to that of the embryos (Zador et al. 1986). The enzyme shows the same number of isozymes (four or five) in larvae and adults as in the head of the fly or in embryos (Zador et al. 1986). In the Df(3R)GE26/MKRS stock both the membrane bound and the soluble enzyme are at about half normal levels while in the Df(3R)AceHD1/MKRS stock this is true only for the membrane bound AChE. Therefore the effect of the above deficiencies in larvae and adults is consistent with that in embryos (Zador et al. 1986). In heat-sensitive combinations of certain Ace mutant alleles both the membrane bound and the soluble enzyme has reduced activity.

Original languageEnglish
Pages (from-to)487-490
Number of pages4
JournalMGG Molecular & General Genetics
Volume218
Issue number3
DOIs
Publication statusPublished - Sep 1 1989

Keywords

  • Acetylcholinesterase
  • Drosophila melanogaster
  • Tissue specific expression

ASJC Scopus subject areas

  • Genetics

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