Tissue resident stem cells: Till death do us part

Hadas Raveh-Amit, Sara Berzsenyi, Virag Vas, Danna Ye, A. Dinnyés

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Aging is accompanied by reduced regenerative capacity of all tissues and organs and dysfunction of adult stem cells. Notably, these age-related alterations contribute to distinct pathophysiological characteristics depending on the tissue of origin and function and thus require special attention in a type by type manner. In this paper, we review the current understanding of the mechanisms leading to tissue-specific adult stem cell dysfunction and reduced regenerative capacity with age. A comprehensive investigation of the hematopoietic, the neural, the mesenchymal, and the skeletal stem cells in age-related research highlights that distinct mechanisms are associated with the different types of tissue stem cells. The link between age-related stem cell dysfunction and human pathologies is discussed along with the challenges and the future perspectives in stem cell-based therapies in age-related diseases.

Original languageEnglish
Pages (from-to)573-590
Number of pages18
JournalBiogerontology
Volume14
Issue number6
DOIs
Publication statusPublished - Dec 2013

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Cell Death
Stem Cells
Adult Stem Cells
Cell- and Tissue-Based Therapy
Mesenchymal Stromal Cells
Pathology
Research

Keywords

  • Adult stem cells
  • Age-related diseases
  • Aging
  • Regeneration
  • Stem cell therapy

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Ageing

Cite this

Tissue resident stem cells : Till death do us part. / Raveh-Amit, Hadas; Berzsenyi, Sara; Vas, Virag; Ye, Danna; Dinnyés, A.

In: Biogerontology, Vol. 14, No. 6, 12.2013, p. 573-590.

Research output: Contribution to journalArticle

Raveh-Amit, H, Berzsenyi, S, Vas, V, Ye, D & Dinnyés, A 2013, 'Tissue resident stem cells: Till death do us part', Biogerontology, vol. 14, no. 6, pp. 573-590. https://doi.org/10.1007/s10522-013-9469-9
Raveh-Amit, Hadas ; Berzsenyi, Sara ; Vas, Virag ; Ye, Danna ; Dinnyés, A. / Tissue resident stem cells : Till death do us part. In: Biogerontology. 2013 ; Vol. 14, No. 6. pp. 573-590.
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