Tissue resident stem cells: Till death do us part

Hadas Raveh-Amit, Sara Berzsenyi, Virag Vas, Danna Ye, Andras Dinnyes

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Aging is accompanied by reduced regenerative capacity of all tissues and organs and dysfunction of adult stem cells. Notably, these age-related alterations contribute to distinct pathophysiological characteristics depending on the tissue of origin and function and thus require special attention in a type by type manner. In this paper, we review the current understanding of the mechanisms leading to tissue-specific adult stem cell dysfunction and reduced regenerative capacity with age. A comprehensive investigation of the hematopoietic, the neural, the mesenchymal, and the skeletal stem cells in age-related research highlights that distinct mechanisms are associated with the different types of tissue stem cells. The link between age-related stem cell dysfunction and human pathologies is discussed along with the challenges and the future perspectives in stem cell-based therapies in age-related diseases.

Original languageEnglish
Pages (from-to)573-590
Number of pages18
JournalBiogerontology
Volume14
Issue number6
DOIs
Publication statusPublished - Dec 1 2013

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Keywords

  • Adult stem cells
  • Age-related diseases
  • Aging
  • Regeneration
  • Stem cell therapy

ASJC Scopus subject areas

  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

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