Tissue plasminogen activator inhibits P-glycoprotein activity in brain endothelial cells

Mária A. Deli, Csongor S. Ábrahám, Hideaki Takahata, Masami Niwa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Tissue plasminogen activator (0.01-30 μg/ml) dose-dependently inhibited the functional activity of P-glycoprotein, assessed by rhodamine 123 accumulation in GP8 immortalized rat brain endothelial cells, but this effect was unrelated to its proteolytic activity. Elevation of intra-endothelial cyclic AMP concentration and stimulation of protein kinase C increased P-glycoprotein activity in GP8 cells and also attenuated the tissue plasminogen activator-induced inhibition.

Original languageEnglish
Pages (from-to)R3-R5
JournalEuropean Journal of Pharmacology
Volume411
Issue number1-2
DOIs
Publication statusPublished - Jan 10 2001

Keywords

  • Blood-brain barrier
  • P-glycoprotein
  • Tissue plasminogen activator

ASJC Scopus subject areas

  • Pharmacology

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