Szöveti hormonsokk: Az intrakrinológia a lokálisan képzodo hormonok szerepe különbözo betegségek patogenezisében

Translated title of the contribution: Tissue hormonal shock: Intracrinology - The importance of locally produced hormones in the pathogenesis of various diseases

Research output: Contribution to journalArticle

Abstract

This review describes the function and tissue-specific expression of the 11- and 17-beta-hydroxysteroid-dehydrogenase enzyme families as well as the aromatase and 1-alpha-hydroxylase enzymes. Recently, in situ formation of active steroids by these enzymes at the sites of their actions from biologically inactive precursors in the circulation have been demonstrated to play an important role in sex steroid-dependent neoplasms (such as breast and prostate cancer), and in some metabolic diseases (such as obesity, osteoporosis and insulin resistance). Tissue-specific Cushing syndrome (local hypercortisolism) may contribute to the pathogenesis of the latter group of diseases, suggesting that obesity may be considered the Cushing-syndrome of the omentum and that osteoporosis is the obesity of bone. Intracrinology is the science of alterations in tissue hormone synthesis catalysed by enzymes such as those mentioned above, which cannot be detected by measuring circulating hormone levels. The effects of local hormone production differ from those of the well-described autocrine, paracrine and endocrine actions. Based on the hormonal changes within various tissues, the pathogenesis of a number of diseases may be interpreted in a novel way.

Original languageHungarian
Pages (from-to)23-30
Number of pages8
JournalLege Artis Medicinae
Volume18
Issue number1
Publication statusPublished - Jan 2008

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Cushing Syndrome
Shock
Hormones
Obesity
Enzymes
Osteoporosis
17-Hydroxysteroid Dehydrogenases
Steroids
11-beta-Hydroxysteroid Dehydrogenases
Omentum
Aromatase
Metabolic Diseases
Mixed Function Oxygenases
Insulin Resistance
Prostatic Neoplasms
Breast Neoplasms
Bone and Bones
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "This review describes the function and tissue-specific expression of the 11- and 17-beta-hydroxysteroid-dehydrogenase enzyme families as well as the aromatase and 1-alpha-hydroxylase enzymes. Recently, in situ formation of active steroids by these enzymes at the sites of their actions from biologically inactive precursors in the circulation have been demonstrated to play an important role in sex steroid-dependent neoplasms (such as breast and prostate cancer), and in some metabolic diseases (such as obesity, osteoporosis and insulin resistance). Tissue-specific Cushing syndrome (local hypercortisolism) may contribute to the pathogenesis of the latter group of diseases, suggesting that obesity may be considered the Cushing-syndrome of the omentum and that osteoporosis is the obesity of bone. Intracrinology is the science of alterations in tissue hormone synthesis catalysed by enzymes such as those mentioned above, which cannot be detected by measuring circulating hormone levels. The effects of local hormone production differ from those of the well-described autocrine, paracrine and endocrine actions. Based on the hormonal changes within various tissues, the pathogenesis of a number of diseases may be interpreted in a novel way.",
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author = "G. Speer and P. Lakatos",
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AB - This review describes the function and tissue-specific expression of the 11- and 17-beta-hydroxysteroid-dehydrogenase enzyme families as well as the aromatase and 1-alpha-hydroxylase enzymes. Recently, in situ formation of active steroids by these enzymes at the sites of their actions from biologically inactive precursors in the circulation have been demonstrated to play an important role in sex steroid-dependent neoplasms (such as breast and prostate cancer), and in some metabolic diseases (such as obesity, osteoporosis and insulin resistance). Tissue-specific Cushing syndrome (local hypercortisolism) may contribute to the pathogenesis of the latter group of diseases, suggesting that obesity may be considered the Cushing-syndrome of the omentum and that osteoporosis is the obesity of bone. Intracrinology is the science of alterations in tissue hormone synthesis catalysed by enzymes such as those mentioned above, which cannot be detected by measuring circulating hormone levels. The effects of local hormone production differ from those of the well-described autocrine, paracrine and endocrine actions. Based on the hormonal changes within various tissues, the pathogenesis of a number of diseases may be interpreted in a novel way.

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KW - Osteoporosis

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