Tissue concentration of the active substance of Voltaren SR 75 in articular cartilage, synovial membrane and bone

T. Bender, M. Schäfer, J. Bariska

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The tissue concentration of diclofenac sodium, the active substance of Voltaren SR 75 mg tablets, was studied in 10 patients with coxarthrosis. Voltaren SR 75 mg tablets were administered twice daily for 5 days, then prosthetic joint replacement of the hip was performed. Tissue levels of diclofenac were determined by HPLC in specimens of articular cartilage, synovial membrane and bone obtained during surgery. The results demonstrate that diclofenac was present in all three tissue types after 5 days of therapy.

Original languageEnglish
Pages (from-to)89-91
Number of pages3
JournalClinical Rheumatology
Volume19
Issue number2
DOIs
Publication statusPublished - 2000

Fingerprint

Synovial Membrane
Diclofenac
Articular Cartilage
Bone and Bones
Tablets
Replacement Arthroplasties
Hip Osteoarthritis
Hip
High Pressure Liquid Chromatography

Keywords

  • HPLC
  • Pharmacokinetic
  • Tissue concentration
  • Voltaren SR 75

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Tissue concentration of the active substance of Voltaren SR 75 in articular cartilage, synovial membrane and bone. / Bender, T.; Schäfer, M.; Bariska, J.

In: Clinical Rheumatology, Vol. 19, No. 2, 2000, p. 89-91.

Research output: Contribution to journalArticle

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