Tuberoinfundibular peptide of 39 residues (TIP39) is a neuropeptide discovered in 1999. TIP39 activates the parathyroid hormone 2 (PTH2) receptor and appears to be its endogenous ligand. TIP39 is synthesized by one group of neurons in the subparafascicular area at the caudal end of the thalamus and by a second group in the medial paralemniscal nucleus in the lateral pons. TIP39 neurons project to a number of limbic-, auditory-, and hypothalamic-related areas, which contain PTH2 receptor expressing fibers. Preliminary data suggest that TIP39 may modulate hypothalamic-releasing hormone secretion, mood- and anxiety-related functions, and nociception.
- Chemical neuroanatomy
- Family B
- G-protein-coupled receptor
- Parathyroid hormone 2 receptor
ASJC Scopus subject areas