TIP39 (Tuberoinfundibular Peptide of 39 Residues)

T. B. Usdin, A. Dobolyi

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)


Tuberoinfundibular peptide of 39 residues (TIP39) is a neuropeptide discovered in 1999. TIP39 activates the parathyroid hormone 2 (PTH2) receptor and appears to be its endogenous ligand. TIP39 is synthesized by one group of neurons in the subparafascicular area at the caudal end of the thalamus and by a second group in the medial paralemniscal nucleus in the lateral pons. TIP39 neurons project to a number of limbic-, auditory-, and hypothalamic-related areas, which contain PTH2 receptor expressing fibers. Preliminary data suggest that TIP39 may modulate hypothalamic-releasing hormone secretion, mood- and anxiety-related functions, and nociception.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages9
ISBN (Print)9780080450469
Publication statusPublished - Jan 1 2009


  • Chemical neuroanatomy
  • Family B
  • G-protein-coupled receptor
  • Limbic
  • Neuromodulator
  • Neuropeptide
  • Paralemniscal
  • Parathyroid hormone 2 receptor
  • Subparafascicular

ASJC Scopus subject areas

  • Neuroscience(all)

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    Usdin, T. B., & Dobolyi, A. (2009). TIP39 (Tuberoinfundibular Peptide of 39 Residues). In Encyclopedia of Neuroscience (pp. 1009-1017). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.02015-5