Time multiplexed active neural probe with 1356 parallel recording sites

Bogdan C. Raducanu, Refet F. Yazicioglu, Carolina M. Lopez, Marco Ballini, Jan Putzeys, Shiwei Wang, Alexandru Andrei, Veronique Rochus, Marleen Welkenhuysen, Nick van Helleputte, Silke Musa, Robert Puers, Fabian Kloosterman, Chris van Hoof, Richárd Fiáth, I. Ulbert, Srinjoy Mitra

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We present a high electrode density and high channel count CMOS (complementary metal-oxide-semiconductor) active neural probe containing 1344 neuron sized recording pixels (20 μm × 20 μm) and 12 reference pixels (20 μm × 80 μm), densely packed on a 50 μm thick, 100 μm wide, and 8 mm long shank. The active electrodes or pixels consist of dedicated in-situ circuits for signal source amplification, which are directly located under each electrode. The probe supports the simultaneous recording of all 1356 electrodes with sufficient signal to noise ratio for typical neuroscience applications. For enhanced performance, further noise reduction can be achieved while using half of the electrodes (678). Both of these numbers considerably surpass the state-of-the art active neural probes in both electrode count and number of recording channels. The measured input referred noise in the action potential band is 12.4 μVrms, while using 678 electrodes, with just 3 μW power dissipation per pixel and 45 μW per read-out channel (including data transmission).

Original languageEnglish
Article number2388
JournalSensors (Switzerland)
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 19 2017

Fingerprint

Electrodes
recording
electrodes
probes
Pixels
pixels
Noise
joints (junctions)
neurology
Semiconductors
Signal-To-Noise Ratio
Neurosciences
Noise abatement
noise reduction
neurons
Data communication systems
Oxides
Action Potentials
Neurons
Amplification

Keywords

  • Active electrode
  • Active neural probes
  • CMOS
  • High density component
  • Neural amplifier
  • Neural array
  • Neural recording

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Biochemistry
  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Raducanu, B. C., Yazicioglu, R. F., Lopez, C. M., Ballini, M., Putzeys, J., Wang, S., ... Mitra, S. (2017). Time multiplexed active neural probe with 1356 parallel recording sites. Sensors (Switzerland), 17(10), [2388]. https://doi.org/10.3390/s17102388

Time multiplexed active neural probe with 1356 parallel recording sites. / Raducanu, Bogdan C.; Yazicioglu, Refet F.; Lopez, Carolina M.; Ballini, Marco; Putzeys, Jan; Wang, Shiwei; Andrei, Alexandru; Rochus, Veronique; Welkenhuysen, Marleen; van Helleputte, Nick; Musa, Silke; Puers, Robert; Kloosterman, Fabian; van Hoof, Chris; Fiáth, Richárd; Ulbert, I.; Mitra, Srinjoy.

In: Sensors (Switzerland), Vol. 17, No. 10, 2388, 19.10.2017.

Research output: Contribution to journalArticle

Raducanu, BC, Yazicioglu, RF, Lopez, CM, Ballini, M, Putzeys, J, Wang, S, Andrei, A, Rochus, V, Welkenhuysen, M, van Helleputte, N, Musa, S, Puers, R, Kloosterman, F, van Hoof, C, Fiáth, R, Ulbert, I & Mitra, S 2017, 'Time multiplexed active neural probe with 1356 parallel recording sites', Sensors (Switzerland), vol. 17, no. 10, 2388. https://doi.org/10.3390/s17102388
Raducanu BC, Yazicioglu RF, Lopez CM, Ballini M, Putzeys J, Wang S et al. Time multiplexed active neural probe with 1356 parallel recording sites. Sensors (Switzerland). 2017 Oct 19;17(10). 2388. https://doi.org/10.3390/s17102388
Raducanu, Bogdan C. ; Yazicioglu, Refet F. ; Lopez, Carolina M. ; Ballini, Marco ; Putzeys, Jan ; Wang, Shiwei ; Andrei, Alexandru ; Rochus, Veronique ; Welkenhuysen, Marleen ; van Helleputte, Nick ; Musa, Silke ; Puers, Robert ; Kloosterman, Fabian ; van Hoof, Chris ; Fiáth, Richárd ; Ulbert, I. ; Mitra, Srinjoy. / Time multiplexed active neural probe with 1356 parallel recording sites. In: Sensors (Switzerland). 2017 ; Vol. 17, No. 10.
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