Time-dependoent increases in Na+,K+-ATPase content of low-frequency-stimulated rabbit muscle

H. J. Green, M. Ball-Burnett, E. R. Chin, L. Dux, D. Pette

Research output: Contribution to journalArticle

24 Citations (Scopus)


Chronic low-frequency stimulation of rabbit fast-twitch muscle induced time-dependent increases in the concentration of the sarcoleminal Na+,K+-ATPase and in mitochondrial citrate synthase activity. The almost twofold increase in Na+,K+-ATPase preceded the rise in citrate synthase and was complete after 10 days of stimulation, We suggest that the increase in Na+,K+-ATPase enhances resistance to fatigue of low-frequency-stimulated muscle prior to elevations in aerobic-oxidative capacity.

Original languageEnglish
Pages (from-to)129-131
Number of pages3
JournalFEBS letters
Issue number2
Publication statusPublished - Sep 28 1992


  • Low-frequency stimulation
  • Muscle fatigue
  • Na/K-ATPase
  • Sarcolemma

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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