Time courses of changes of para-, meta-, and ortho-tyrosine in septic patients: A pilot study

Lívia Szélig, Szilárd Kun, Gábor Woth, Gergő A. Molnár, Zita Zrínyi, Emese Kátai, J. Lantos, I. Wittmann, L. Bogár, A. Miseta, Csaba Csontos

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: Sepsis is associated with oxidative stress. Due to oxidative stress, three tyrosine isoforms, para-, meta-, and ortho-tyrosine (p-, m-, and o-Tyr), can be formed non-enzymatically in smaller amounts. p-Tyr is mainly formed physiologically in the kidneys through the activity of the phenylalanine hydroxylase enzyme. The three tyrosine isoforms may undergo different renal handling. Methods: Twenty septic patients were involved in the study and 25 healthy individuals served as controls. Blood and urine levels of p-, m-, and o-Tyr were measured on admission and four consecutive days. Results: Serum m-Tyr levels were higher in septic patients than in controls on days 2 (P = 0.031) and 3 (P = 0.035). Serum p-Tyr levels were lower in the cases than in controls on days 1 (P = 0.005) and 2 (P = 0.040), and subsequently normalized due to a day-by-day elevation (P = 0.002). The tendency of urinary m-Tyr concentration was decreasing (P = 0.041), while that of urinary p-Tyr concentration was increasing (P = 0.001). Fractional excretion of m-Tyr (FEm -Tyr) showed a decreasing tendency (P = 0.009), and was, on all days, higher than FEp -Tyr, which remained near-normal, less than 4%. Procalcitonin showed significant correlation with FEm -Tyr (r = 0.454; P < 0.001). Discussion: Our data suggest that the oxidative stress marker m-Tyr and physiologic p-Tyr may be handled differently in septic patients. The excretion of m-Tyr correlates with inflammation. m-Tyr may be actively secreted or produced in the kidney in some patients, whereas the decreased serum level of p-Tyr is a consequence of diminished renal production and not of renal loss.

Original languageEnglish
Pages (from-to)180-189
Number of pages10
JournalRedox Report
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 3 2016

Fingerprint

Oxidative stress
Kidney
Tyrosine
Protein Isoforms
Oxidative Stress
Phenylalanine Hydroxylase
Calcitonin
Serum
Blood
Enzymes
Sepsis
2-tyrosine
3-tyrosine
Urine
Inflammation

Keywords

  • Acute renal failure
  • Hydroxyl radical
  • Oxidative stress
  • Sepsis
  • Tyrosine

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

Szélig, L., Kun, S., Woth, G., Molnár, G. A., Zrínyi, Z., Kátai, E., ... Csontos, C. (2016). Time courses of changes of para-, meta-, and ortho-tyrosine in septic patients: A pilot study. Redox Report, 21(4), 180-189. https://doi.org/10.1179/1351000215Y.0000000028

Time courses of changes of para-, meta-, and ortho-tyrosine in septic patients : A pilot study. / Szélig, Lívia; Kun, Szilárd; Woth, Gábor; Molnár, Gergő A.; Zrínyi, Zita; Kátai, Emese; Lantos, J.; Wittmann, I.; Bogár, L.; Miseta, A.; Csontos, Csaba.

In: Redox Report, Vol. 21, No. 4, 03.07.2016, p. 180-189.

Research output: Contribution to journalArticle

Szélig, Lívia ; Kun, Szilárd ; Woth, Gábor ; Molnár, Gergő A. ; Zrínyi, Zita ; Kátai, Emese ; Lantos, J. ; Wittmann, I. ; Bogár, L. ; Miseta, A. ; Csontos, Csaba. / Time courses of changes of para-, meta-, and ortho-tyrosine in septic patients : A pilot study. In: Redox Report. 2016 ; Vol. 21, No. 4. pp. 180-189.
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AU - Kun, Szilárd

AU - Woth, Gábor

AU - Molnár, Gergő A.

AU - Zrínyi, Zita

AU - Kátai, Emese

AU - Lantos, J.

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AU - Bogár, L.

AU - Miseta, A.

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