Time course of pro- and anti-inflammatory cytokine levels in patients with burns-Prognostic value of interleukin-10

C. Csontos, V. Foldi, L. Pálinkas, L. Bogar, E. Röth, G. Weber, J. Lantos

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Introduction: Trends and the prognostic value of cytokine responses to severe burns have not been fully examined in humans. Therefore, the aim of this study was to determine the time course and prognostic value of pro- and anti-inflammatory cytokines in the immediate post-burn period. Patients and methods: Blood samples were taken for measuring IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α concentrations from patients with more than 20% burned surface area on admission and on 5 consecutive days. Development of sepsis was assessed using standard criteria twice a day. Results: IL-12p70 remained under assay detection levels in the study period. IL-1β and TNF-α could be detected in stimulated blood samples with higher levels in survivors (n = 21). IL-6 on days 4-5 and IL-8 on days 4-6 in non-stimulated plasma showed significant elevation in non-survivors (n = 18) whereas in stimulated blood its levels did not differ significantly. IL-10 levels were significantly higher in non-survivors during the study period in non-stimulated, and except day 6 in stimulated blood. Using the cut-off level of 14 pg ml-1 for IL-10 predicted ICU mortality with 85.4% sensitivity and 84.2% specificity on admission. Conclusion: Early anti-inflammatory excess had a bad prognosis for patients suffering from severe burns.

Original languageEnglish
Pages (from-to)483-494
Number of pages12
JournalBurns
Volume36
Issue number4
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Burns
Interleukin-10
Anti-Inflammatory Agents
Cytokines
Interleukin-8
Interleukin-1
Interleukin-6
Survivors
Sepsis
Sensitivity and Specificity
Mortality

Keywords

  • Burn injury
  • Interleukin-10
  • Interleukin-1beta
  • Interleukin-6
  • Interleukin-8
  • Tumour necrosis factor-alpha

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

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title = "Time course of pro- and anti-inflammatory cytokine levels in patients with burns-Prognostic value of interleukin-10",
abstract = "Introduction: Trends and the prognostic value of cytokine responses to severe burns have not been fully examined in humans. Therefore, the aim of this study was to determine the time course and prognostic value of pro- and anti-inflammatory cytokines in the immediate post-burn period. Patients and methods: Blood samples were taken for measuring IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α concentrations from patients with more than 20{\%} burned surface area on admission and on 5 consecutive days. Development of sepsis was assessed using standard criteria twice a day. Results: IL-12p70 remained under assay detection levels in the study period. IL-1β and TNF-α could be detected in stimulated blood samples with higher levels in survivors (n = 21). IL-6 on days 4-5 and IL-8 on days 4-6 in non-stimulated plasma showed significant elevation in non-survivors (n = 18) whereas in stimulated blood its levels did not differ significantly. IL-10 levels were significantly higher in non-survivors during the study period in non-stimulated, and except day 6 in stimulated blood. Using the cut-off level of 14 pg ml-1 for IL-10 predicted ICU mortality with 85.4{\%} sensitivity and 84.2{\%} specificity on admission. Conclusion: Early anti-inflammatory excess had a bad prognosis for patients suffering from severe burns.",
keywords = "Burn injury, Interleukin-10, Interleukin-1beta, Interleukin-6, Interleukin-8, Tumour necrosis factor-alpha",
author = "C. Csontos and V. Foldi and L. P{\'a}linkas and L. Bogar and E. R{\"o}th and G. Weber and J. Lantos",
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T1 - Time course of pro- and anti-inflammatory cytokine levels in patients with burns-Prognostic value of interleukin-10

AU - Csontos, C.

AU - Foldi, V.

AU - Pálinkas, L.

AU - Bogar, L.

AU - Röth, E.

AU - Weber, G.

AU - Lantos, J.

PY - 2010/6

Y1 - 2010/6

N2 - Introduction: Trends and the prognostic value of cytokine responses to severe burns have not been fully examined in humans. Therefore, the aim of this study was to determine the time course and prognostic value of pro- and anti-inflammatory cytokines in the immediate post-burn period. Patients and methods: Blood samples were taken for measuring IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α concentrations from patients with more than 20% burned surface area on admission and on 5 consecutive days. Development of sepsis was assessed using standard criteria twice a day. Results: IL-12p70 remained under assay detection levels in the study period. IL-1β and TNF-α could be detected in stimulated blood samples with higher levels in survivors (n = 21). IL-6 on days 4-5 and IL-8 on days 4-6 in non-stimulated plasma showed significant elevation in non-survivors (n = 18) whereas in stimulated blood its levels did not differ significantly. IL-10 levels were significantly higher in non-survivors during the study period in non-stimulated, and except day 6 in stimulated blood. Using the cut-off level of 14 pg ml-1 for IL-10 predicted ICU mortality with 85.4% sensitivity and 84.2% specificity on admission. Conclusion: Early anti-inflammatory excess had a bad prognosis for patients suffering from severe burns.

AB - Introduction: Trends and the prognostic value of cytokine responses to severe burns have not been fully examined in humans. Therefore, the aim of this study was to determine the time course and prognostic value of pro- and anti-inflammatory cytokines in the immediate post-burn period. Patients and methods: Blood samples were taken for measuring IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α concentrations from patients with more than 20% burned surface area on admission and on 5 consecutive days. Development of sepsis was assessed using standard criteria twice a day. Results: IL-12p70 remained under assay detection levels in the study period. IL-1β and TNF-α could be detected in stimulated blood samples with higher levels in survivors (n = 21). IL-6 on days 4-5 and IL-8 on days 4-6 in non-stimulated plasma showed significant elevation in non-survivors (n = 18) whereas in stimulated blood its levels did not differ significantly. IL-10 levels were significantly higher in non-survivors during the study period in non-stimulated, and except day 6 in stimulated blood. Using the cut-off level of 14 pg ml-1 for IL-10 predicted ICU mortality with 85.4% sensitivity and 84.2% specificity on admission. Conclusion: Early anti-inflammatory excess had a bad prognosis for patients suffering from severe burns.

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KW - Interleukin-10

KW - Interleukin-1beta

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KW - Tumour necrosis factor-alpha

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