Tight junctional changes upon microwave and X-ray irradiation

Z. Pálfia, Z. Somosy, G. Réz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Tight junctions (zonulae occludentes, ZO) are cellularly regulated dynamic structures sensitive to environmental stress agents including ionizing radiation. Radiation induced pathological alterations of the small intestine (gastrointestinal radiation syndrome) are related to altered ZO-mediated paracellular transport. We carried out a quantitative morphological evaluation of the murine jejunal epithelial tight junctional structure in freeze fracture replicas as changed upon whole body X-ray irradiation and low energy microwave exposition. X-ray treatment (4 Gy, 1, 24 h) brought about a partial dearrangement of the ZO strand network which regenerated only partially by 24 h. This observation is in line with data on paracellular permeability increases and ZO-bound calcium drop caused by X-ray irradiation. On the other hand, microwave treatment (16 Hz-modulated 2.45 GHz wave, 1 mW/cm2 power density, 1 h exposition, samples at 1 and 3 h after exposition) did not cause dearrangement but, rather an increase in the integration of thight junctional structure, which is in agreement with an increase in cytochemically detectable ZO-bound calcium.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalActa Biologica Hungarica
Volume52
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

Microwaves
irradiation
X-radiation
X-Rays
Irradiation
X rays
calcium
Calcium
Radiation
Radiation Injuries
tight junctions
microwave treatment
Tight Junctions
Ionizing radiation
environmental stress
Ionizing Radiation
ionizing radiation
Small Intestine
small intestine
Permeability

Keywords

  • Freeze-fracture
  • Microwave
  • Tight junction
  • X-ray
  • Zonula occludens

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Tight junctional changes upon microwave and X-ray irradiation. / Pálfia, Z.; Somosy, Z.; Réz, G.

In: Acta Biologica Hungarica, Vol. 52, No. 4, 2001, p. 411-416.

Research output: Contribution to journalArticle

Pálfia, Z. ; Somosy, Z. ; Réz, G. / Tight junctional changes upon microwave and X-ray irradiation. In: Acta Biologica Hungarica. 2001 ; Vol. 52, No. 4. pp. 411-416.
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