Tidal changes in respiratory resistance are sensitive indicators of airway obstruction in children

Dorottya Czövek, Claire Shackleton, Z. Hantos, Kate Taylor, Anushma Kumar, Archana Chacko, Robert S. Ware, Gergely Makan, Bence Radics, Z. Gingl, Peter D. Sly

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Rationale: Individual assessment of airway obstruction in preschool-age children requires sensitive and specific lung function methods with low demand of cooperation. Although the forced oscillation technique (FOT) is feasible in young children, conventional measurements of respiratory impedance (Zrs) have limited diagnostic power in individuals. Objective: To find descriptors of within-breath Zrs that are sensitive indicators of airway obstruction during tidal breathing in children. Methods: Zrs was measured with (i) a standard multifrequency FOT (4-26 Hz) to assess the mean values of resistance and reactance for whole breaths and (ii) a 10 Hz signal to track the within-breath changes. Various Zrs measures obtained in healthy children (n=75) and those with acute wheeze (n=31) were investigated with receiver operator characteristic (ROC) analysis. The cut-off values obtained for airway obstruction were then tested in children with recurrent wheeze (n=20) before and after administration of salbutamol. Results: The largest area under the ROC curve (0.95) was observed for the tidal changes of resistance between the zero-flow values (ÄR). The ΔR cut-off value of 1.42 hPa s/L detected airway obstruction with sensitivity of 92% and specificity of 89% in children with acute wheeze and distinguished children with recurrent wheeze (16/20 above the cut-off value) from healthy children (22/23 below the cut-off value). Furthermore, ΔR significantly decreased after salbutamol in wheezy children but remained unchanged in healthy children. Conclusions: New lung function measure ΔR is able to detect airway obstruction with high sensitivity and specificity and is suitable for use in lung function testing in young children.

Original languageEnglish
Pages (from-to)907-915
Number of pages9
JournalThorax
Volume71
Issue number10
DOIs
Publication statusPublished - 2016

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Airway Obstruction
Albuterol
Lung
Sensitivity and Specificity
Preschool Children
Electric Impedance
Respiration

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Czövek, D., Shackleton, C., Hantos, Z., Taylor, K., Kumar, A., Chacko, A., ... Sly, P. D. (2016). Tidal changes in respiratory resistance are sensitive indicators of airway obstruction in children. Thorax, 71(10), 907-915. https://doi.org/10.1136/thoraxjnl-2015-208182

Tidal changes in respiratory resistance are sensitive indicators of airway obstruction in children. / Czövek, Dorottya; Shackleton, Claire; Hantos, Z.; Taylor, Kate; Kumar, Anushma; Chacko, Archana; Ware, Robert S.; Makan, Gergely; Radics, Bence; Gingl, Z.; Sly, Peter D.

In: Thorax, Vol. 71, No. 10, 2016, p. 907-915.

Research output: Contribution to journalArticle

Czövek, D, Shackleton, C, Hantos, Z, Taylor, K, Kumar, A, Chacko, A, Ware, RS, Makan, G, Radics, B, Gingl, Z & Sly, PD 2016, 'Tidal changes in respiratory resistance are sensitive indicators of airway obstruction in children', Thorax, vol. 71, no. 10, pp. 907-915. https://doi.org/10.1136/thoraxjnl-2015-208182
Czövek, Dorottya ; Shackleton, Claire ; Hantos, Z. ; Taylor, Kate ; Kumar, Anushma ; Chacko, Archana ; Ware, Robert S. ; Makan, Gergely ; Radics, Bence ; Gingl, Z. ; Sly, Peter D. / Tidal changes in respiratory resistance are sensitive indicators of airway obstruction in children. In: Thorax. 2016 ; Vol. 71, No. 10. pp. 907-915.
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AU - Shackleton, Claire

AU - Hantos, Z.

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AU - Kumar, Anushma

AU - Chacko, Archana

AU - Ware, Robert S.

AU - Makan, Gergely

AU - Radics, Bence

AU - Gingl, Z.

AU - Sly, Peter D.

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N2 - Rationale: Individual assessment of airway obstruction in preschool-age children requires sensitive and specific lung function methods with low demand of cooperation. Although the forced oscillation technique (FOT) is feasible in young children, conventional measurements of respiratory impedance (Zrs) have limited diagnostic power in individuals. Objective: To find descriptors of within-breath Zrs that are sensitive indicators of airway obstruction during tidal breathing in children. Methods: Zrs was measured with (i) a standard multifrequency FOT (4-26 Hz) to assess the mean values of resistance and reactance for whole breaths and (ii) a 10 Hz signal to track the within-breath changes. Various Zrs measures obtained in healthy children (n=75) and those with acute wheeze (n=31) were investigated with receiver operator characteristic (ROC) analysis. The cut-off values obtained for airway obstruction were then tested in children with recurrent wheeze (n=20) before and after administration of salbutamol. Results: The largest area under the ROC curve (0.95) was observed for the tidal changes of resistance between the zero-flow values (ÄR). The ΔR cut-off value of 1.42 hPa s/L detected airway obstruction with sensitivity of 92% and specificity of 89% in children with acute wheeze and distinguished children with recurrent wheeze (16/20 above the cut-off value) from healthy children (22/23 below the cut-off value). Furthermore, ΔR significantly decreased after salbutamol in wheezy children but remained unchanged in healthy children. Conclusions: New lung function measure ΔR is able to detect airway obstruction with high sensitivity and specificity and is suitable for use in lung function testing in young children.

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