Thyroxine-induced cardiomegaly

Assessment of nucleic acid, protein content and myosin ATPase of rat heart

J. Szabó, K. Nosztray, I. Takacs, J. Szegi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1 mg/kg L-thyroxine was administered to rats for 14 days to evaluate the potential of the hyperthyroid state to induce heart hypertrophy and its effect on myosin adenosine-triphosphatase (ATPase) activity. Evidence of hyperthyroidism such as weight loss, elevation of rectal temperature, increased heart rate and oxygen consumption, was observed in all treated rats. Cardiac enlargement was determined by comparison of wet and dry ventricle weights, myocardial RNA, DNA and protein content. Wet and dry ventricle weights and the level of cardiac RNA and protein were augmented by thyroxine treatment. ATPase activity of cardiac myosin was stimulated as the Ca2+ concentration in the incubation medium increased. No difference was found in Ca2+-activation, salt sensitivity or ATPase activity of unreacted and sulfydryl-modified cardiac myosins from euthyroid or hyperthyroid groups. The results showed that in hyperthyroid rats, in contrast to some other species, the biochemical mechanism responsible for the enhancement of cardiac contractility is not an increased myosin ATPase.

Original languageEnglish
Pages (from-to)69-79
Number of pages11
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume54
Issue number1
Publication statusPublished - 1980

Fingerprint

Cardiomegaly
Hyperthyroidism
Myosins
Thyroxine
Nucleic Acids
Cardiac Myosins
Adenosine Triphosphatases
Proteins
RNA
Weights and Measures
Oxygen Consumption
Weight Loss
Salts
Heart Rate
Temperature
DNA

ASJC Scopus subject areas

  • Physiology

Cite this

Thyroxine-induced cardiomegaly : Assessment of nucleic acid, protein content and myosin ATPase of rat heart. / Szabó, J.; Nosztray, K.; Takacs, I.; Szegi, J.

In: Acta Physiologica Academiae Scientiarum Hungaricae, Vol. 54, No. 1, 1980, p. 69-79.

Research output: Contribution to journalArticle

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