Thyrotropin (TSH) regulates triiodothyronine (T 3) production in the unicellular Tetrahymena

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of the experiments was to study the regulation of triiodothyronine (T 3) production in the unicellular Tetrahymena. Untreated and troph-hormone treated specimen were prepared and in different timepoints T 3 content was measured and compared by immunocytochemical flow cytometry. 0.1 or 0.001 IU TSH in tryptone-yeast medium stimulated T 3 synthesis at 10, 20, 30 min, but does not stimulate after 1 h. The overlapping gonadotropic hormone (GTH) also did it, however only at 10 min. In Losina salt solution (physiological for Tetrahymena) the effect was weaker, however outer amino acid source was not absolutely needed for the production of the hormone. The results show that the TSH regulation of thyroid hormone synthesis (storage, secretion) and troph-hormone overlap can be deduced to a unicellular level. This may allow the hypothesis that the endocrine mechanisms proved at a low level of phylogeny are preserved for the higher ranked organisms.

Original languageEnglish
Pages (from-to)228-234
Number of pages7
JournalActa Biologica Hungarica
Volume62
Issue number3
DOIs
Publication statusPublished - Sep 1 2011

Fingerprint

Tetrahymena
Triiodothyronine
Thyrotropin
hormone
Hormones
Flow cytometry
Phylogeny
Thyroid Hormones
Yeast
flow cytometry
Flow Cytometry
Salts
secretion
Yeasts
yeast
Amino Acids
phylogeny
amino acid
salt
Experiments

Keywords

  • endocrine
  • hormonal overlap
  • Hormone evolution
  • phylogeny
  • Tetrahymena

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

Cite this

Thyrotropin (TSH) regulates triiodothyronine (T 3) production in the unicellular Tetrahymena. / Csaba, G.; Pállinger, E.

In: Acta Biologica Hungarica, Vol. 62, No. 3, 01.09.2011, p. 228-234.

Research output: Contribution to journalArticle

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