Thyrotropin releasing hormone (TRH)

A new player in human hair-growth control

Erzsébet Gáspár, Celine Hardenbicker, E. Bódó, Björn Wenzel, Yuval Ramot, Wolfgang Funk, Arno Kromminga, Ralf Paus

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Thyrotropin-releasing hormone (TRH) is the most proximal component of the hypothalamicpituitary-thyroid axis that regulates thyroid hormone synthesis. Since transcripts for members of this axis were detected in cultured normal human skin cells and since human hair follicles (HFs) respond to stimulation with thyrotropin, we now have studied whether human HF functions are also modulated by TRH. Here we report that the epithelium of normal human scalp HFs expresses not only TRH receptors (TRH-R) but also TRH itself at the gene and protein level. Stimulation of microdissected, organ-cultured HFs with TRH promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen), and antagonizes its termination by TGF-β2. It also increases proliferation and inhibits apoptosis of hair matrix keratinocytes. These TRH effects may be mediated in part by reducing the ATM/Atr-dependent phosphorylation of p53. By microarray analysis, several differentially up- or down-regulated TRH-target genes were detected (e.g., selected keratins). Thus, human scalp HFs are both a source and a target of TRH, which operates as a potent hair-growth stimulator. Human HFs provide an excellent discovery tool for identifying and dissecting nonclassical functions of TRH and TRH-mediated signaling in situ, which emerge as novel players in human epithelial biology.

Original languageEnglish
Pages (from-to)393-403
Number of pages11
JournalFASEB Journal
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Thyrotropin-Releasing Hormone
Hair
Hair Follicle
Growth
Scalp
Thyrotropin Releasing Hormone Receptors
Phosphorylation
Automatic teller machines
Thyrotropin
Microarray Analysis
Microarrays
Keratins
Thyroid Hormones
Keratinocytes
Elongation
Skin
Thyroid Gland
Epithelium
Genes
Apoptosis

Keywords

  • Cell cycle
  • Hair cycle regulation
  • Hair follicle

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics
  • Molecular Biology

Cite this

Gáspár, E., Hardenbicker, C., Bódó, E., Wenzel, B., Ramot, Y., Funk, W., ... Paus, R. (2010). Thyrotropin releasing hormone (TRH): A new player in human hair-growth control. FASEB Journal, 24(2), 393-403. https://doi.org/10.1096/fj.08-126417

Thyrotropin releasing hormone (TRH) : A new player in human hair-growth control. / Gáspár, Erzsébet; Hardenbicker, Celine; Bódó, E.; Wenzel, Björn; Ramot, Yuval; Funk, Wolfgang; Kromminga, Arno; Paus, Ralf.

In: FASEB Journal, Vol. 24, No. 2, 02.2010, p. 393-403.

Research output: Contribution to journalArticle

Gáspár, E, Hardenbicker, C, Bódó, E, Wenzel, B, Ramot, Y, Funk, W, Kromminga, A & Paus, R 2010, 'Thyrotropin releasing hormone (TRH): A new player in human hair-growth control', FASEB Journal, vol. 24, no. 2, pp. 393-403. https://doi.org/10.1096/fj.08-126417
Gáspár, Erzsébet ; Hardenbicker, Celine ; Bódó, E. ; Wenzel, Björn ; Ramot, Yuval ; Funk, Wolfgang ; Kromminga, Arno ; Paus, Ralf. / Thyrotropin releasing hormone (TRH) : A new player in human hair-growth control. In: FASEB Journal. 2010 ; Vol. 24, No. 2. pp. 393-403.
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