Thyreoidea stimuláló hormont termelö hypophysis adenoma.

Translated title of the contribution: Thyroid-stimulating hormone-secreting pituitary adenoma

M. Tóth, K. Rácz, R. Kiss, L. Fütö, I. Varga, K. Karlinger, E. Dékány, S. Czirják, E. Pásztor, E. Gláz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 40-year-old male patient with a 2 years history of recurring hyperthyroidism is presented with clinical hyperthyroidism and diffuse goiter. Despite thyreostatic treatment and surgical thyroid ablation the hyperthyroidism recurred. The patient had laboratory evidence of hyperthyroidism and his serum TSH was persistently and enormously elevated (T4:214 nmol/l, T3:6.9 nmol/l, TSH:218 mIU/l)> Computed tomography and magnetic resonance imaging confirmed a pituitary mass of 7 cm in a-p diameter, with supra-, parasellar and sphenoidal extension. The pituitary adenoma was partially resected by transsphenoidal surgery, which failed to result in a substantial decrease in the serum thyrotropin level. Pituitary irradiation and a long-term somatostatin analog octreotide treatment (300-600 micrograms/die) combined with bromocriptine therapy resulted in a significant, but still incomplete suppression of thyrotropin secretion (TSH level about 15 mIU/l) and persisting mild hyperthyroidism. The size of the adenoma was unchanged during the two years of highdose octreotide treatment period. According to our best knowledge this is the first reported case of a thyrotropin-secreting pituitary adenoma in Hungary.

Translated title of the contributionThyroid-stimulating hormone-secreting pituitary adenoma
Original languageHungarian
Pages (from-to)2709-2712
Number of pages4
JournalOrvosi hetilap
Volume135
Issue number49
Publication statusPublished - Dec 4 1994

ASJC Scopus subject areas

  • Medicine(all)

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