Thyroid hormones and complement parameters in hereditary angioedema with C1-inhibitor deficiency

Ibolya Czaller, Dorottya Csuka, Zsuzsanna Zotter, Nóra Veszeli, Edit Takács, Éva Imreh, L. Varga, H. Farkas

Research output: Contribution to journalArticle

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Abstract

Background: Thyroid hormones control and up-regulate the synthesis of many plasma proteins. Objective: To explore possible associations between thyroid hormone and complement levels in patients with hereditary angioedema resulting from the deficiency of the C1-inhibitor (C1-INH-HAE). Methods: In this case-control study, serum thyrotropin, free triiodothyronine (FT3), and free thyroxine (FT4) levels, anti-thyroid peroxidase and antithyroglobulin antibody titers, and C1-INH concentrations were measured in 117 euthyroid patients with C1-INH-HAE and compared with their clinical properties. The control group comprised 150 healthy, age- and sex-matched, euthyroid individuals. Results: The thyrotropin and antithyroglobulin levels were similar between the patients and the controls. Significantly lower FT3 (P <.001) and FT4 (P = .002) levels, as well as higher anti-thyroid peroxidase titers (P <.001), were seen in the patients with C1-INH-HAE. The proportion of patients with reduced C1-INH activity was greater among those with below-median FT4 levels than among those with above-median values (P = .02). Patients who experienced more edematous attacks per year had lower FT4 levels (within the normal range) than those afflicted by fewer episodes (P = .01). The FT3 and FT4 levels were significantly higher in patients undergoing long-term danazol therapy than in those who did not receive this drug (P = .01 and P = .02, respectively). The proportion of patients with FT4 levels in the below-median range was higher in the subset with increased d-dimer concentration (P = .009). Conclusion: Minor variations of the thyroid hormone levels (within the reference range) can influence the function of C1-INH in C1-INH-HAE. Our findings suggest a role for the endocrine system in the pathophysiology of C1-INH-HAE.

Original languageEnglish
JournalAnnals of Allergy, Asthma and Immunology
DOIs
Publication statusAccepted/In press - Mar 22 2016

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Hereditary Angioedemas
Thyroid Hormones
Iodide Peroxidase
Thyrotropin
Reference Values
Danazol
Endocrine System
Triiodothyronine
Thyroxine
Case-Control Studies
Blood Proteins
Up-Regulation
Control Groups

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Thyroid hormones and complement parameters in hereditary angioedema with C1-inhibitor deficiency. / Czaller, Ibolya; Csuka, Dorottya; Zotter, Zsuzsanna; Veszeli, Nóra; Takács, Edit; Imreh, Éva; Varga, L.; Farkas, H.

In: Annals of Allergy, Asthma and Immunology, 22.03.2016.

Research output: Contribution to journalArticle

Czaller, Ibolya ; Csuka, Dorottya ; Zotter, Zsuzsanna ; Veszeli, Nóra ; Takács, Edit ; Imreh, Éva ; Varga, L. ; Farkas, H. / Thyroid hormones and complement parameters in hereditary angioedema with C1-inhibitor deficiency. In: Annals of Allergy, Asthma and Immunology. 2016.
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AU - Czaller, Ibolya

AU - Csuka, Dorottya

AU - Zotter, Zsuzsanna

AU - Veszeli, Nóra

AU - Takács, Edit

AU - Imreh, Éva

AU - Varga, L.

AU - Farkas, H.

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