Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum

Attila Zsarnovszky, David Kiss, Gergely Jocsak, Gabor Nemeth, Istvan Toth, Tamas L. Horvath

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Although the effects of phytoestrogens on brain function is widely unknown, they are often regarded as “natural” and thus as harmless. However, the effects of phytoestrogens or environmental pollutants on brain function is underestimated. Estrogen (17beta-estradiol, E2) and thyroid hormones (THs) play pivotal roles in brain development. In the mature brain, these hormones regulate metabolism on cellular and organismal levels. Thus, E2 and THs do not only regulate the energy metabolism of the entire organism, but simultaneously also regulate important homeostatic parameters of neurons and glia in the CNS. It is, therefore, obvious that the mechanisms through which these hormones exert their effects are pleiotropic and include both intra- and intercellular actions. These hormonal mechanisms are versatile, and the experimental investigation of simultaneous hormone-induced mechanisms is technically challenging. In addition, the normal physiological settings of metabolic parameters depend on a plethora of interactions of the steroid hormones. In this review, we discuss conceptual and experimental aspects of the gonadal and thyroid hormones as they relate to in vitro models of the cerebellum.

Original languageEnglish
Pages (from-to)23-36
Number of pages14
JournalFrontiers in Neuroendocrinology
Volume48
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Cerebellum
  • Estradiol
  • Neuronal and glial culture
  • Thyrod hormone

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems

Fingerprint Dive into the research topics of 'Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum'. Together they form a unique fingerprint.

  • Cite this