Thyroid gland paraganglioma: Report of a case and review of the literature

Nhung Annhong Nguyen, Ilona Peter, Bernadett Levay, Judit Andi, C. Polgár, Nagy Z. Takácsi

Research output: Contribution to journalReview article


Background: The uncommon thyroid associated paraganglioma is supposed to be originating from the inferior laryngeal paraganglia. Differential diagnosis is most problematic, chromogranin A, synaptophysin and S100 protein are immunohistochemical markers of this tumor. Patient and method: A 66-year old woman presented with an asymptomatic left side anterior neck mass. Ultrasound-guided fine needle aspiration cytology, scintigraphy and computed tomography, magnetic resonance imaging scans showed the presence of a benign thyroid nodule. Half year later it began to grow and caused soreness. Left thyroid lobectomy was carried out and a non-Hürthle cell follicular carcinoma with positive resection margin was found. To complete total thyroidectomy, right side lobectomy and isthmus resection were done without finding any further malignancy. Pathological revision of the left lobe specimen with additional immunohistochemical examination (positive staining for chromogranin A and synaptophysin, negative staining for thyreoglobulin and calcitonin, while some of the tumor cells were S100 positive) proved the tumor to be a malignant thyroid paraganglioma. As the resection margin of the left lobectomy was positive, the patient received adjuvant radiotherapy (60 Gy/2 Gy/day to the thyroid bed). During the follow-up time (18 months) the patient is alive, with no evidence of disease. Conclusion: Since the diagnosis of paraganglioma is usually problematic, recognition of this rare entity is very important. Adjunctive immunohistochemical methods play essential role in distinguishing it from other thyroid diseases. Radiotherapy can be considered as alternative primary treatment, but it is necessary, especially for treating residual tumor.

Original languageEnglish
Article numberIJCEM0056785
Pages (from-to)16703-16708
Number of pages6
JournalInternational Journal of Clinical and Experimental Medicine
Issue number12
Publication statusPublished - Jan 1 2017


  • Immunohistochemistry
  • Malignant
  • Paraganglioma
  • Radiotherapy
  • Thyroid gland

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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