Thymocyte death by neglect: Contribution of engulfing macrophages

Zsuzsa Szondy, Éva Garabuczi, Katalin Tóth, Bea Kiss, Krisztina Köröskényi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The thymus provides the microenvironment in which thymocytes develop into mature T cells, and interactions with thymic stromal cells are thought to provide the necessary signals for thymocyte maturation. Recognition of self-MHC by T cells is a basic requirement for mature T-cell functions, and those thymocytes that do not recognize the peptide-loaded self-MHC molecules found in the thymus, and therefore lack a TCR signal, undergo a default death pathway named "death by neglect" in the thymic cortex. In the absence of this TCR signaling, it has been suggested that binding of glucocorticoids to - or the ligation of certain cell surface molecules, such as CD8, CD24, CD45, or CD99 on - these neglected thymocytes will induce them to enter the apoptotic program. Apoptotic thymocytes are cleared by the surrounding macrophages and, as a consequence, these macrophages are known to release various molecules, such as adenosine, retinoids, TGF-β, ATP, and carbon monoxide. Interestingly, all these molecules have been described to induce or promote apoptosis in thymocytes in the absence of TCR signaling. Here, we propose that thymic macrophages, because they continually engulf apoptotic cells, might constantly provide these cell death-inducing signals, and thus contribute to the formation of a thymic milieu that ensures the effective induction of "death by neglect".

Original languageEnglish
Pages (from-to)1662-1667
Number of pages6
JournalEuropean Journal of Immunology
Volume42
Issue number7
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Thymocytes
Macrophages
T-Lymphocytes
Thymus Gland
Retinoids
Carbon Monoxide
Stromal Cells
Cell Communication
Adenosine
Glucocorticoids
Ligation
Cell Death
Adenosine Triphosphate
Apoptosis
Peptides

Keywords

  • Apoptosis
  • Macrophages
  • Phagocytosis
  • Thymic selection

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Thymocyte death by neglect : Contribution of engulfing macrophages. / Szondy, Zsuzsa; Garabuczi, Éva; Tóth, Katalin; Kiss, Bea; Köröskényi, Krisztina.

In: European Journal of Immunology, Vol. 42, No. 7, 07.2012, p. 1662-1667.

Research output: Contribution to journalArticle

Szondy, Zsuzsa ; Garabuczi, Éva ; Tóth, Katalin ; Kiss, Bea ; Köröskényi, Krisztina. / Thymocyte death by neglect : Contribution of engulfing macrophages. In: European Journal of Immunology. 2012 ; Vol. 42, No. 7. pp. 1662-1667.
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