Thrombocytopenia in Newcastle disease: Haematological evaluation and histological study of bone marrow

Norma L. Calderón, Felipa Galindo-Muñiz, Mireya Ortiz, B. Lomniczi, T. Fehervari, L. H. Paasch

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A Newcastle disease virus (NDV) isolated in Mexico and called Chimalhuacan strain was characterised by gene F restriction enzyme analysis and found to be a genotype II velogenic virus. Haematological evaluations and histological studies of bone marrow were conducted on chickens experimentally infect with the Chimalhuacan virus and on control chickens. Within 72 hours post infection (hpi), a 50% decrease in thrombocyte and monocyte counts and a complet cellular depletion in bone marrow islands were evident in the infected group. These findings suggest that the Chimalhuacan strain of NDV causes an early and severe damage of the haematopoietic cells including thrombocyte precursors, which might explain the marked thrombocytopenia detected in early stages of this disease.

Original languageEnglish
Pages (from-to)507-513
Number of pages7
JournalActa Veterinaria Hungarica
Volume53
Issue number4
DOIs
Publication statusPublished - 2005

Fingerprint

Newcastle Disease
blood platelets
Newcastle disease virus
thrombocytopenia
Newcastle disease
Thrombocytopenia
bone marrow
Chickens
Blood Platelets
Bone Marrow
chickens
Viruses
viruses
Restriction Mapping
restriction mapping
Mexico
monocytes
Monocytes
Genotype
genotype

Keywords

  • Bone marrow
  • Newcastle disease
  • Pathology
  • Thrombocytopenia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Thrombocytopenia in Newcastle disease : Haematological evaluation and histological study of bone marrow. / Calderón, Norma L.; Galindo-Muñiz, Felipa; Ortiz, Mireya; Lomniczi, B.; Fehervari, T.; Paasch, L. H.

In: Acta Veterinaria Hungarica, Vol. 53, No. 4, 2005, p. 507-513.

Research output: Contribution to journalArticle

Calderón, Norma L. ; Galindo-Muñiz, Felipa ; Ortiz, Mireya ; Lomniczi, B. ; Fehervari, T. ; Paasch, L. H. / Thrombocytopenia in Newcastle disease : Haematological evaluation and histological study of bone marrow. In: Acta Veterinaria Hungarica. 2005 ; Vol. 53, No. 4. pp. 507-513.
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