Three-plane description of astroglial populations of OVLT subdivisions in rat

Tanycyte connections to distant parts of third ventricle

M. Kálmán, Erzsébet Oszwald, Károly Pócsai

Research output: Contribution to journalArticle

Abstract

This study demonstrates glial and gliovascular markers of organon vasculosum laminae terminalis (OVLT) in three planes. The distribution of glial markers displayed similarities to the subfornical organ. There was an inner part with vimentin- and nestin-immunopositive glia whereas GFAP and the water-channel aquaporin 4 were found at the periphery. This separation indicates different functions of the two regions. The presence of nestin may indicate stem cell-capabilities whereas aquaporin 4 has been reported to promote the osmoreceptor function. Glutamine synthetase immunoreactivity was sparse like in the area postrema and subfornical organ. The laminin and β-dystroglycan immunolabelings altered along the vessels such as in the subfornical organ indicating altering gliovascular relations. The different subdivisions of OVLT received glial processes of different origins. The posterior periventricular zone contained short vimentin-immunopositive processes from the ependyma of the adjacent surface of the third ventricle. The lateral periventricular zone received forceps-like process systems from the anterolateral part of the third ventricle. Most interestingly, the “dorsal cap” received a mixed group of long GFAP- and vimentin-immunopositive processes from a distant part of the third ventricle. The processes may have two functions: a guidance for newly produced cells like radial glia in immature brain and/or a connection between distant parts of the third ventricle and OVLT.

Original languageEnglish
JournalJournal of Comparative Neurology
DOIs
Publication statusPublished - Jan 1 2019

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Third Ventricle
Neuroglia
Subfornical Organ
Vimentin
Aquaporin 4
Nestin
Population
Dystroglycans
Ependyma
Area Postrema
Glutamate-Ammonia Ligase
Aquaporins
Laminin
Surgical Instruments
Stem Cells
Organum Vasculosum
Brain

Keywords

  • aquaporin 4
  • dystroglycan
  • GFAP
  • laminin
  • nestin
  • RRID:AB 10013382
  • RRID:AB 141708
  • RRID:AB 142924
  • RRID:AB 228357
  • RRID:AB 2536180
  • RRID:AB 258,270
  • RRID:AB 350537
  • RRID:AB 397880
  • RRID:AB 442043
  • RRID:AB 477163
  • RRID:AB 563739
  • RRID:AB 94911
  • vimentin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Three-plane description of astroglial populations of OVLT subdivisions in rat: Tanycyte connections to distant parts of third ventricle",
abstract = "This study demonstrates glial and gliovascular markers of organon vasculosum laminae terminalis (OVLT) in three planes. The distribution of glial markers displayed similarities to the subfornical organ. There was an inner part with vimentin- and nestin-immunopositive glia whereas GFAP and the water-channel aquaporin 4 were found at the periphery. This separation indicates different functions of the two regions. The presence of nestin may indicate stem cell-capabilities whereas aquaporin 4 has been reported to promote the osmoreceptor function. Glutamine synthetase immunoreactivity was sparse like in the area postrema and subfornical organ. The laminin and β-dystroglycan immunolabelings altered along the vessels such as in the subfornical organ indicating altering gliovascular relations. The different subdivisions of OVLT received glial processes of different origins. The posterior periventricular zone contained short vimentin-immunopositive processes from the ependyma of the adjacent surface of the third ventricle. The lateral periventricular zone received forceps-like process systems from the anterolateral part of the third ventricle. Most interestingly, the “dorsal cap” received a mixed group of long GFAP- and vimentin-immunopositive processes from a distant part of the third ventricle. The processes may have two functions: a guidance for newly produced cells like radial glia in immature brain and/or a connection between distant parts of the third ventricle and OVLT.",
keywords = "aquaporin 4, dystroglycan, GFAP, laminin, nestin, RRID:AB 10013382, RRID:AB 141708, RRID:AB 142924, RRID:AB 228357, RRID:AB 2536180, RRID:AB 258,270, RRID:AB 350537, RRID:AB 397880, RRID:AB 442043, RRID:AB 477163, RRID:AB 563739, RRID:AB 94911, vimentin",
author = "M. K{\'a}lm{\'a}n and Erzs{\'e}bet Oszwald and K{\'a}roly P{\'o}csai",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/cne.24707",
language = "English",
journal = "Journal of Comparative Neurology",
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TY - JOUR

T1 - Three-plane description of astroglial populations of OVLT subdivisions in rat

T2 - Tanycyte connections to distant parts of third ventricle

AU - Kálmán, M.

AU - Oszwald, Erzsébet

AU - Pócsai, Károly

PY - 2019/1/1

Y1 - 2019/1/1

N2 - This study demonstrates glial and gliovascular markers of organon vasculosum laminae terminalis (OVLT) in three planes. The distribution of glial markers displayed similarities to the subfornical organ. There was an inner part with vimentin- and nestin-immunopositive glia whereas GFAP and the water-channel aquaporin 4 were found at the periphery. This separation indicates different functions of the two regions. The presence of nestin may indicate stem cell-capabilities whereas aquaporin 4 has been reported to promote the osmoreceptor function. Glutamine synthetase immunoreactivity was sparse like in the area postrema and subfornical organ. The laminin and β-dystroglycan immunolabelings altered along the vessels such as in the subfornical organ indicating altering gliovascular relations. The different subdivisions of OVLT received glial processes of different origins. The posterior periventricular zone contained short vimentin-immunopositive processes from the ependyma of the adjacent surface of the third ventricle. The lateral periventricular zone received forceps-like process systems from the anterolateral part of the third ventricle. Most interestingly, the “dorsal cap” received a mixed group of long GFAP- and vimentin-immunopositive processes from a distant part of the third ventricle. The processes may have two functions: a guidance for newly produced cells like radial glia in immature brain and/or a connection between distant parts of the third ventricle and OVLT.

AB - This study demonstrates glial and gliovascular markers of organon vasculosum laminae terminalis (OVLT) in three planes. The distribution of glial markers displayed similarities to the subfornical organ. There was an inner part with vimentin- and nestin-immunopositive glia whereas GFAP and the water-channel aquaporin 4 were found at the periphery. This separation indicates different functions of the two regions. The presence of nestin may indicate stem cell-capabilities whereas aquaporin 4 has been reported to promote the osmoreceptor function. Glutamine synthetase immunoreactivity was sparse like in the area postrema and subfornical organ. The laminin and β-dystroglycan immunolabelings altered along the vessels such as in the subfornical organ indicating altering gliovascular relations. The different subdivisions of OVLT received glial processes of different origins. The posterior periventricular zone contained short vimentin-immunopositive processes from the ependyma of the adjacent surface of the third ventricle. The lateral periventricular zone received forceps-like process systems from the anterolateral part of the third ventricle. Most interestingly, the “dorsal cap” received a mixed group of long GFAP- and vimentin-immunopositive processes from a distant part of the third ventricle. The processes may have two functions: a guidance for newly produced cells like radial glia in immature brain and/or a connection between distant parts of the third ventricle and OVLT.

KW - aquaporin 4

KW - dystroglycan

KW - GFAP

KW - laminin

KW - nestin

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KW - RRID:AB 142924

KW - RRID:AB 228357

KW - RRID:AB 2536180

KW - RRID:AB 258,270

KW - RRID:AB 350537

KW - RRID:AB 397880

KW - RRID:AB 442043

KW - RRID:AB 477163

KW - RRID:AB 563739

KW - RRID:AB 94911

KW - vimentin

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U2 - 10.1002/cne.24707

DO - 10.1002/cne.24707

M3 - Article

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

ER -