Three New Iridoid Glycosides from the Aerial Parts of Asperula involucrata

Hasan Kırmızıbekmez, Kubilay Tiftik, Norbert Kúsz, Orsolya Orban-Gyapai, Zoltán Péter Zomborszki, Judit Hohmann

Research output: Contribution to journalArticle

2 Citations (Scopus)


Three new iridoid glycosides, named involucratosides A – C (1 – 3), were isolated from the H2O subextract of crude MeOH extract prepared from the aerial parts of Asperula involucrata along with a known iridoid glycoside (adoxoside), three flavone glycosides (apigenin 7-O-β-glucopyranoside, luteolin 7-O-β-glucopyranoside, apigenin 7-O-rutinoside) as well as two phenolic acid derivatives (chlorogenic acid and ferulic acid 4-O-β-glucopyranoside). Their chemical structures were established by UV, IR, 1D- (1H, 13C and JMOD) and 2D- (COSY, HSQC, HMBC and NOESY) NMR experiments and HR-ESI-MS. In addition, the crude extract, subextracts and isolates were evaluated for their xanthine oxidase inhibitory and antioxidant activities in in vitro tests. This is the first report on the chemical composition and bioactivities of A. involucrata.

Original languageEnglish
Article numbere1600288
JournalChemistry and Biodiversity
Issue number3
Publication statusPublished - Mar 1 2017


  • Antioxidant activities
  • Asperula involucrata
  • Involucratosides A – C
  • Iridoid glycosides
  • Rubiaceae
  • Xanthine oxidase inhibitory activities

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Kırmızıbekmez, H., Tiftik, K., Kúsz, N., Orban-Gyapai, O., Zomborszki, Z. P., & Hohmann, J. (2017). Three New Iridoid Glycosides from the Aerial Parts of Asperula involucrata. Chemistry and Biodiversity, 14(3), [e1600288].