Three-generation investigation on serotonin content in rat immune cells long after β-endorphin exposure in late pregnancy

G. Csaba, C. Karabélyos, Á Inczefi-Conda, É Pállinger

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Female rats were treated with β-endorphin on the 19th day of pregnancy. Serotonin content of immune cells (peritoneal lymphocytes, monocyte-macrophage-granulocyte group (mo-gran), mast cells, blood lymphocytes, granulocytes and monocytes, thymus lymphocytes) were studied in the mothers (P-generation four weeks after delivery), in the male offspring (F1) generation (at seven weeks), in the female offspring (four weeks after their own delivery) and in their offspring (F2 generation, at seven weeks). P-mother cells' serotonin content was not influenced by endorphin treatment, while F1 generation's mo-gran and blood lymphocyte serotonin content was reduced (in contrast, histamine content of mo-gran increased). Four weeks after delivery, an increase in serotonin content was observed in the F 1 generation in the peritoneal lymphocytes and mast cells as well as in blood lymphocytes. In contrast, serotonin content was reduced in blood granulocytes and monocytes. In the F2 (grandson) generation, a reduction in mast cell serotonin content and sensitization of blood and thymic lymphocytes to repeated endorphin treatment was provoked. The significant changes were more expressed in the F2 generation compared to F 1, also appearing earlier. The results unequivocally suggest that the increase in endorphin levels during late pregnancy can cause permanent changes in the F1 and F2 generations, which means that the imprinting effect can be transgenerationally transmitted.

Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalHormone and Metabolic Research
Volume37
Issue number3
DOIs
Publication statusPublished - Mar 1 2005

Keywords

  • Endorphin
  • Hormonal imprinting
  • Mast cells
  • Serotonin
  • Transgenerational effect
  • White blood cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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