Three distinct components of the negative inotropic action of lidocaine in dog Purkinje fiber

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Abstract

1. The negative inotropic action of 10 μM lidocaine and 100 μM nicorandil was compared as a function of the pacing cycle length, ranging from 300-3000 ms, in isolated canine Purkinje fiber preparations. 2. The applied concentrations of lidocaine and nicorandil produced similar shortening of action potential duration; however, lidocaine compromised contractility stronger than nicorandil at each cycle length. 3. Normalizing the inotropic action of the drugs to their shortening effect on action potential duration, the negative inotropic action of lidocaine can be regarded as a sum of three distinct components: negative inotropy associated to the shortening of action potential duration per se, reduction of contractility likely due to direct inhibition of the fast sodium current and of the 'window' sodium current by lidocaine.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalGeneral Pharmacology
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1996

Keywords

  • Action potential duration
  • Anti-arrhythmic drugs
  • Cardiac contractility
  • Electrophysiology
  • Negative inotropy
  • Sodium channels

ASJC Scopus subject areas

  • Pharmacology

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