Three-dimensional speckle tracking echocardiography allows detailed evaluation of left atrial function in hypertrophic cardiomyopathy-insights from the MAGYAR-Path Study

Péter Domsik, Anita Kalapos, Számi Chadaide, Róbert Sepp, Péter Hausinger, T. Forster, Attila Nemes

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Introduction: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. Reduced left atrial (LA) function was demonstrated in HCM by different methods. Three-dimensional (3D) speckle tracking echocardiography (STE) has just been introduced for the evaluation of LA. This study was designed to compare 3DSTE-derived LA volumetric and strain parameters in HCM with healthy controls. Methods: The study comprised 23 consecutive HCM patients (mean age: 48.5 ± 15.1 years, 14 men). Their results were compared to 23 age- and gender-matched healthy controls. Complete two-dimensional Doppler echocardiography and 3DSTE have been performed in all cases. Results: Calculated LA maximum (66.4 ± 20.4 mL vs. 36.0 ± 6.1 mL, P <0.0001) and minimum (39.2 ± 19.1 vs. 16.0 ± 4.6 mL, P <0.0001) volumes and LA volume before atrial contraction (53.6 ± 19.9 vs. 24.0 ± 6.2 mL, P <0.0001) were significantly increased in HCM patients. Atrial stroke volumes respecting cardiac cycles proved to be increased, while emptying fractions were decreased in subjects with HCM. Mean global radial (-12.2 ± 6.7% vs. -19.6 ± 11.7, P <0.05), longitudinal (26.5 ± 16.5% vs. 29.8 ± 12.1%, P <0.05) and 3D strain (-6.1 ± 4.4% vs. -12.5 ± 10.2%, P <0.05) proved to be significantly reduced in HCM patients as compared with matched controls. Conclusions: Three-dimensional speckle tracking echocardiography allows detailed evaluation of LA (dys) function in HCM by volumetric and strain measurements.

Original languageEnglish
Pages (from-to)1245-1252
Number of pages8
JournalEchocardiography
Volume31
Issue number10
DOIs
Publication statusPublished - Nov 1 2014

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Left Atrial Function
Hypertrophic Cardiomyopathy
Echocardiography
Doppler Echocardiography
Stroke Volume
Myocardium

Keywords

  • Echocardiography
  • Function
  • Hypertrophic cardiomyopathy
  • Left atrium
  • Speckle tracking
  • Three-dimensional

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Three-dimensional speckle tracking echocardiography allows detailed evaluation of left atrial function in hypertrophic cardiomyopathy-insights from the MAGYAR-Path Study. / Domsik, Péter; Kalapos, Anita; Chadaide, Számi; Sepp, Róbert; Hausinger, Péter; Forster, T.; Nemes, Attila.

In: Echocardiography, Vol. 31, No. 10, 01.11.2014, p. 1245-1252.

Research output: Contribution to journalArticle

Domsik, Péter ; Kalapos, Anita ; Chadaide, Számi ; Sepp, Róbert ; Hausinger, Péter ; Forster, T. ; Nemes, Attila. / Three-dimensional speckle tracking echocardiography allows detailed evaluation of left atrial function in hypertrophic cardiomyopathy-insights from the MAGYAR-Path Study. In: Echocardiography. 2014 ; Vol. 31, No. 10. pp. 1245-1252.
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abstract = "Introduction: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. Reduced left atrial (LA) function was demonstrated in HCM by different methods. Three-dimensional (3D) speckle tracking echocardiography (STE) has just been introduced for the evaluation of LA. This study was designed to compare 3DSTE-derived LA volumetric and strain parameters in HCM with healthy controls. Methods: The study comprised 23 consecutive HCM patients (mean age: 48.5 ± 15.1 years, 14 men). Their results were compared to 23 age- and gender-matched healthy controls. Complete two-dimensional Doppler echocardiography and 3DSTE have been performed in all cases. Results: Calculated LA maximum (66.4 ± 20.4 mL vs. 36.0 ± 6.1 mL, P <0.0001) and minimum (39.2 ± 19.1 vs. 16.0 ± 4.6 mL, P <0.0001) volumes and LA volume before atrial contraction (53.6 ± 19.9 vs. 24.0 ± 6.2 mL, P <0.0001) were significantly increased in HCM patients. Atrial stroke volumes respecting cardiac cycles proved to be increased, while emptying fractions were decreased in subjects with HCM. Mean global radial (-12.2 ± 6.7{\%} vs. -19.6 ± 11.7, P <0.05), longitudinal (26.5 ± 16.5{\%} vs. 29.8 ± 12.1{\%}, P <0.05) and 3D strain (-6.1 ± 4.4{\%} vs. -12.5 ± 10.2{\%}, P <0.05) proved to be significantly reduced in HCM patients as compared with matched controls. Conclusions: Three-dimensional speckle tracking echocardiography allows detailed evaluation of LA (dys) function in HCM by volumetric and strain measurements.",
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AU - Domsik, Péter

AU - Kalapos, Anita

AU - Chadaide, Számi

AU - Sepp, Róbert

AU - Hausinger, Péter

AU - Forster, T.

AU - Nemes, Attila

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N2 - Introduction: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. Reduced left atrial (LA) function was demonstrated in HCM by different methods. Three-dimensional (3D) speckle tracking echocardiography (STE) has just been introduced for the evaluation of LA. This study was designed to compare 3DSTE-derived LA volumetric and strain parameters in HCM with healthy controls. Methods: The study comprised 23 consecutive HCM patients (mean age: 48.5 ± 15.1 years, 14 men). Their results were compared to 23 age- and gender-matched healthy controls. Complete two-dimensional Doppler echocardiography and 3DSTE have been performed in all cases. Results: Calculated LA maximum (66.4 ± 20.4 mL vs. 36.0 ± 6.1 mL, P <0.0001) and minimum (39.2 ± 19.1 vs. 16.0 ± 4.6 mL, P <0.0001) volumes and LA volume before atrial contraction (53.6 ± 19.9 vs. 24.0 ± 6.2 mL, P <0.0001) were significantly increased in HCM patients. Atrial stroke volumes respecting cardiac cycles proved to be increased, while emptying fractions were decreased in subjects with HCM. Mean global radial (-12.2 ± 6.7% vs. -19.6 ± 11.7, P <0.05), longitudinal (26.5 ± 16.5% vs. 29.8 ± 12.1%, P <0.05) and 3D strain (-6.1 ± 4.4% vs. -12.5 ± 10.2%, P <0.05) proved to be significantly reduced in HCM patients as compared with matched controls. Conclusions: Three-dimensional speckle tracking echocardiography allows detailed evaluation of LA (dys) function in HCM by volumetric and strain measurements.

AB - Introduction: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. Reduced left atrial (LA) function was demonstrated in HCM by different methods. Three-dimensional (3D) speckle tracking echocardiography (STE) has just been introduced for the evaluation of LA. This study was designed to compare 3DSTE-derived LA volumetric and strain parameters in HCM with healthy controls. Methods: The study comprised 23 consecutive HCM patients (mean age: 48.5 ± 15.1 years, 14 men). Their results were compared to 23 age- and gender-matched healthy controls. Complete two-dimensional Doppler echocardiography and 3DSTE have been performed in all cases. Results: Calculated LA maximum (66.4 ± 20.4 mL vs. 36.0 ± 6.1 mL, P <0.0001) and minimum (39.2 ± 19.1 vs. 16.0 ± 4.6 mL, P <0.0001) volumes and LA volume before atrial contraction (53.6 ± 19.9 vs. 24.0 ± 6.2 mL, P <0.0001) were significantly increased in HCM patients. Atrial stroke volumes respecting cardiac cycles proved to be increased, while emptying fractions were decreased in subjects with HCM. Mean global radial (-12.2 ± 6.7% vs. -19.6 ± 11.7, P <0.05), longitudinal (26.5 ± 16.5% vs. 29.8 ± 12.1%, P <0.05) and 3D strain (-6.1 ± 4.4% vs. -12.5 ± 10.2%, P <0.05) proved to be significantly reduced in HCM patients as compared with matched controls. Conclusions: Three-dimensional speckle tracking echocardiography allows detailed evaluation of LA (dys) function in HCM by volumetric and strain measurements.

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KW - Speckle tracking

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