Three-dimensional measurement of gestational and yolk sac volumes as predictors of pregnancy outcome in the first trimester

A. Babinszki, T. Nyári, S. Jordan, A. Nasseri, T. Mukherjee, A. B. Copperman

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Along with crown-rump length (CRL), the size (diameter) of embryonic structures such as gestational sac (GS) and yolk sac (YS) may have prognostic value for embryonic development. We proposed that first-trimester volume calculations of these structures using transvaginal three-dimensional ultrasound technique may have value as predictors of adverse reproductive outcome. Forty-nine consecutive patients (treated for infertility) with singleton pregnancies were included in this prospective study. Seventy-three examinations were performed in case of pregnancies with normal, and 12 with abnormal outcome. GS and YS volumes were plotted against gestational age (GA) (25-65 days post ovulation) to create nomograms for normal outcome and the same procedure was carried out with CRL measurements as well. Measurements of abnormal pregnancies were compared with these nomograms. Specificity, sensitivity, positive and negative predictive values were also calculated. Regression analysis revealed a power correlation between GS volumes and GA, logarithmic relationship was observed when YS volumes were plotted against GA. CRL showed logarithmic correlation with GA as well. Both GS volumetry and CRL measurements proved to have statistically significant predictive value for adverse outcome (p

Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalAmerican Journal of Perinatology
Volume18
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

Gestational Sac
Crown-Rump Length
Yolk Sac
First Pregnancy Trimester
Pregnancy Outcome
Gestational Age
Nomograms
Pregnancy
Ovulation
Infertility
Embryonic Development
Embryonic Structures
Regression Analysis
Prospective Studies
Sensitivity and Specificity

Keywords

  • Gestational sac
  • Three-dimensional volumetry
  • Yolk sac

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Three-dimensional measurement of gestational and yolk sac volumes as predictors of pregnancy outcome in the first trimester. / Babinszki, A.; Nyári, T.; Jordan, S.; Nasseri, A.; Mukherjee, T.; Copperman, A. B.

In: American Journal of Perinatology, Vol. 18, No. 4, 2001, p. 203-211.

Research output: Contribution to journalArticle

Babinszki, A. ; Nyári, T. ; Jordan, S. ; Nasseri, A. ; Mukherjee, T. ; Copperman, A. B. / Three-dimensional measurement of gestational and yolk sac volumes as predictors of pregnancy outcome in the first trimester. In: American Journal of Perinatology. 2001 ; Vol. 18, No. 4. pp. 203-211.
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