A familiáris hasnyálmirigyrák

Translated title of the contribution: This review emphasizes the importance of these goals. Zalatnai A. Familial pancreatic cancer

Research output: Contribution to journalArticle

Abstract

Familial clustering is estimated in 5-10% of pancreatic cancers. In different countries Familial Pancreatic Cancer Registries have been established to investigate the epidemiology, and genetic background in these families and, to organize the screening programs for high-risk relatives and for follow-up. The largest such registry is found at Johns Hopkins University Hospital. Evaluating the available date revealed that familial pancreatic cancer is heterogeneous: it may occur in kindreds of pancreatic cancer patients, but it may also be associated with various familial cancer syndromes. Such syndromes include FAMMM-syndrome, hereditary breast cancer, Peutz-Jeghers syndrome, but other associations can also be taken into account. The germline mutations are also heterogeneous, and although they are not absolutely decisive, they significantly increase the risk of the affected persons, making the organ more susceptible for environmental carcinogens. High-risk family members should be screened for gene mutations (especially for BRCA2, STK11/LKB1, CDKN2A/p16, PRSS1 genes), and by using endoscopic ultrasound. These methods are useful for identifying the preneoplastic conditions, but of equal importance is the cessation of smoking. In Hungary there are no relevant data about the epidemiology of familial pancreatic cancer, but their number is estimated to be about 80-150 annually. Considering the very high (and continuously increasing) incidence, it seems to be necessary to register and screen these families. This review emphasizes the importance of these goals.

Original languageHungarian
Pages (from-to)163-168
Number of pages6
JournalMagyar Onkologia
Volume50
Issue number2
Publication statusPublished - 2006

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Pancreatic Neoplasms
Registries
Epidemiology
Precancerous Conditions
Peutz-Jeghers Syndrome
Environmental Carcinogens
p16 Genes
Hungary
Germ-Line Mutation
Smoking Cessation
Cluster Analysis
Breast Neoplasms
Mutation
Incidence
Genes
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A familiáris hasnyálmirigyrák. / Zalatnai, A.

In: Magyar Onkologia, Vol. 50, No. 2, 2006, p. 163-168.

Research output: Contribution to journalArticle

Zalatnai, A 2006, 'A familiáris hasnyálmirigyrák', Magyar Onkologia, vol. 50, no. 2, pp. 163-168.
Zalatnai, A. / A familiáris hasnyálmirigyrák. In: Magyar Onkologia. 2006 ; Vol. 50, No. 2. pp. 163-168.
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