Thionation using fluorous Lawesson's reagent

Zoltán Kaleta, Brian T. Makowski, T. Soós, Roman Dembinski

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Thionation of amides, 1,4-diketones, N-(2-oxoalkyl)amides, N,N-acylhydrazines, and acyl-protected uridines with the use of a fluorous analogue of the Lawesson's reagent leads to thioamides, thiophenes, 1,3-thiazoles, 1,3,4-thiadiazoles, and acyl-protected 4-thiouridines. The isolation of the final products in high yields is achieved in most cases by a simple filtration (fluorous solid-phase extraction).

Original languageEnglish
Pages (from-to)1625-1628
Number of pages4
JournalOrganic Letters
Volume8
Issue number8
DOIs
Publication statusPublished - Apr 13 2006

Fingerprint

2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide
Amides
amides
reagents
Thiouridine
Thioamides
Thiazoles
Thiophenes
Uridine
Solid Phase Extraction
thiophenes
solid phases
isolation
analogs
products

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Kaleta, Z., Makowski, B. T., Soós, T., & Dembinski, R. (2006). Thionation using fluorous Lawesson's reagent. Organic Letters, 8(8), 1625-1628. https://doi.org/10.1021/ol060208a

Thionation using fluorous Lawesson's reagent. / Kaleta, Zoltán; Makowski, Brian T.; Soós, T.; Dembinski, Roman.

In: Organic Letters, Vol. 8, No. 8, 13.04.2006, p. 1625-1628.

Research output: Contribution to journalArticle

Kaleta, Z, Makowski, BT, Soós, T & Dembinski, R 2006, 'Thionation using fluorous Lawesson's reagent', Organic Letters, vol. 8, no. 8, pp. 1625-1628. https://doi.org/10.1021/ol060208a
Kaleta Z, Makowski BT, Soós T, Dembinski R. Thionation using fluorous Lawesson's reagent. Organic Letters. 2006 Apr 13;8(8):1625-1628. https://doi.org/10.1021/ol060208a
Kaleta, Zoltán ; Makowski, Brian T. ; Soós, T. ; Dembinski, Roman. / Thionation using fluorous Lawesson's reagent. In: Organic Letters. 2006 ; Vol. 8, No. 8. pp. 1625-1628.
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