As a continuation of our previous study in TLC line (1, 6) we shall consider the TLC separation of estrone its ethers and acetate as well as their oximes and their rearrangement products namely the D-homo-aza-lactams. Comparative examinations and structural identification of homo-aza-lactams occurring in Beckmann rearrangement and Schmidt reaction were described in some of our earlier publications (5, 7). The D-homo-aza-lactams derived from the esterone and estrone 3-methyl ether, were described by Regan and Hayes (9) and we too, carried out the completion of these examinations (4). Numerous papers, summaries, and books (2, 3, 8) describe the TLC separation of estrone and its derivatives occurring in nature due to their biological importance. Consequently our paper can furnish a completion from a preparative organic chemical viewpoint concerning the separation of the above mentioned rearrangement products.
ASJC Scopus subject areas
- Analytical Chemistry