Thiamine pyrophosphatase activity in neurotubuli and synaptic vesicles

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Synaptic vesicles in axon terminals of the rat spinal cord exert thiamine pyrophosphatase activity, confined to elementary granules within the cavities of synaptic vesicles. Some activity was found to be associated with axonal and dendritic tubuli. It is concluded that thiamine pyrophosphatase, synthesized in the perikaryal rough surfaced endoplasmic reticulum and concentrated in the internal Golgi cisterns, is transported via axonal tubuli to the terminal, to be accumulated by synaptic vesicles. The role of thiamine pyrophosphatase and related substances in synaptic transmission is hypothesized.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
Issue number5
Publication statusPublished - Dec 1 1973


ASJC Scopus subject areas

  • Neuroscience(all)

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