Thermostability of Newcastle disease virus strains of different virulence

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Abstract

The thermal inactivation rate constant for infectivity of a total of 24 Newcastle disease virus (NDV) strains was determined at 50° and 56° C. The greater part of the examined NDV strains were found, irrespective of virulence properties, to be thermostable, since the loss of infectivity titre did not exceed 2 logarithmic orders after exposure at 50° C for 60 minutes. Thermostable (I+) and thermolabile (I-) strains with respect to infectivity were uniformly encountered among the 12 avirulent (lentogenic) and 10 fully virulent (velogenic) strains studied. Strains with both heat stable (Ha+) and heat labile (Ha-) haemagglutinin were found in the lentogenic group, whereas haemagglutinins of all examined velogenic strains were heat stable. On the basis of I/Ha character, i.e. combination of thermosensitivity of infectivity and haemagglutinin, all examined strains could be classified into one of three categories: I-Ha- (8 lentogenic strains), I+Ha+ (4 lentogenic and 7 velogenic strains) and I-Ha+ (2 mesogenic and 3 velogenic strains). The possible fourth combination, I+Ha-, was not encountered among the strains studied. Determination of the I/Ha character may be helpful in clarifying the origin of a lentogenic NDV strain.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalArchives of Virology
Volume47
Issue number3
DOIs
Publication statusPublished - Sep 1975

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Newcastle disease virus
Virulence
Hemagglutinins
Hot Temperature

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics
  • Medicine(all)

Cite this

Thermostability of Newcastle disease virus strains of different virulence. / Lomniczi, B.

In: Archives of Virology, Vol. 47, No. 3, 09.1975, p. 249-255.

Research output: Contribution to journalArticle

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