Thermoregulatory effects of D-met2-pro5-enkephalinamide

Margit Szikszay, G. Benedek, J. I. Székely

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Changes elicited in the body temperature by subcutaneous injection of the synthetic D-met2-pro5-enkephalinamide (D-met2-pro5-EA) were studied in CFY rats. D-met2-pro5-EA in doses of 8, 20 and 40 mg/kg caused hyperthermia. If the animals were restrained, this hyperthermic effect was attenuated. Ten mg/kg naloxone completely prevented the elevation of body temperature. Previous administration of 300 mg/kg capsaicin in fractionated daily doses resulted in a facilitation of the hyperthermic reaction. In contrast to other opioids, hypothermia was never observed. Our observations support: the concept of multiple opiate-sensitive mechanisms in thermoregulation.

Original languageEnglish
Pages (from-to)465-475
Number of pages11
JournalNeuropeptides
Volume3
Issue number6
DOIs
Publication statusPublished - 1983

Fingerprint

Body Temperature
Opiate Alkaloids
Hypothermia
Body Temperature Regulation
Capsaicin
Subcutaneous Injections
Naloxone
Opioid Analgesics
Rats
Animals
Fever
Temperature

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Thermoregulatory effects of D-met2-pro5-enkephalinamide. / Szikszay, Margit; Benedek, G.; Székely, J. I.

In: Neuropeptides, Vol. 3, No. 6, 1983, p. 465-475.

Research output: Contribution to journalArticle

Szikszay, Margit ; Benedek, G. ; Székely, J. I. / Thermoregulatory effects of D-met2-pro5-enkephalinamide. In: Neuropeptides. 1983 ; Vol. 3, No. 6. pp. 465-475.
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