Thermodynamic aspects of cancer: Possible role of negative entropy in tumor growth, its relation to kinetic and genetic resistance

Joseph Molnar, Barry S. Thornton, Annamaria Molnar, Dezso Gaál, Liaofu Luo, Elke S. Bergmann-Leitner

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Chemotherapy can result in partial or temporary remission, but often does not completely eradicate cancer. The treatment failures are, at least in part, due to tumor cell resistance to chemotherapeutics. One contributing factor for impaired responses to chemotherapy is that only proliferating cells are affected by the action of chemotherapeutic drugs (kinetic resistance of tumors). Another contributing factor is the genetic resistance mediated by genes encoding proteins such as ABC transporters. A basic understanding of changes associated with tumorigenesis is needed to design and deploy novel and effective strategies for treating cancers. This paper focuses on aspects of energy flow and entropy in tumorigenesis and changes in the interaction between cancer cells and the host. We propose that correlating those changes with the progression of tumors will assist in the design and deployment of novel and more efficacious strategies for chemotherapy and combined therapies.

Original languageEnglish
Pages (from-to)429-438
Number of pages10
JournalLetters in Drug Design and Discovery
Volume2
Issue number6
DOIs
Publication statusPublished - Sep 1 2005

Keywords

  • Cancer cells
  • Drug resistance
  • Entropy
  • Thermogenesis
  • Tumor growth

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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