Thermodynamic and structural characterization of the macrochelates formed in the reactions of copper(II) and zinc(II) ions with peptides of histidine

C. Kállay, K. Várnagy, Gerasimos Malandrinos, Nick Hadjiliadis, Daniele Sanna, I. Sóvágó

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Copper(II) complexes of the peptides Ac-HisSarHis-NH2, Ac-HisSarHisSarHis-NH2 and Ac-HisSarHisSarHisSarHis-NH2 have been studied by potentiometric, UV-Vis, CD and EPR spectroscopic methods. Stability constants for the corresponding zinc(II) complexes have also been reported. The formation of M(II)-2Nim, M(II)-3Nim and M(II)-4Nim bonded macrochelates was suggested in the pH range 5-7. The macrochelates were, however, not stable enough to prevent metal ion hydrolysis in slightly alkaline solutions. In the case of copper(II) complexes, the metal ion promoted deprotonation and coordination of the amide groups of histidyl residues were also suggested. The stability constants of macrochelate complexes were compared to the literature data reported for the macrochelates of the other peptides of histidine. It was found that the thermodynamic stability of macrochelate species is largely influenced by the number and location of histidyl residues in the peptide backbone. The highest stability was obtained for the HXHYH-type sequences, while the distant arrangement of histidyl residues resulted in a significant reduction of the stability constants.

Original languageEnglish
Pages (from-to)935-945
Number of pages11
JournalInorganica Chimica Acta
Volume362
Issue number3
DOIs
Publication statusPublished - Feb 20 2009

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histidine
Histidine
Peptides
peptides
Zinc
Copper
zinc
Thermodynamics
Ions
copper
thermodynamics
Metal ions
ions
metal ions
Deprotonation
Amides
Paramagnetic resonance
Hydrolysis
Thermodynamic stability
amides

Keywords

  • Copper(II)
  • Histidine
  • Macrochelate
  • Peptides
  • Sarcosine
  • Zinc(II)

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Thermodynamic and structural characterization of the macrochelates formed in the reactions of copper(II) and zinc(II) ions with peptides of histidine. / Kállay, C.; Várnagy, K.; Malandrinos, Gerasimos; Hadjiliadis, Nick; Sanna, Daniele; Sóvágó, I.

In: Inorganica Chimica Acta, Vol. 362, No. 3, 20.02.2009, p. 935-945.

Research output: Contribution to journalArticle

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