Thermochemical study on the ring closure reaction of 5-morpholino-4- vinylpyridazinones by tert-amino effect

László Károlyházy, Géza Regdon, Olivér Éliás, Gyula Beke, T. Tábi, K. Pintye-Hódi, I. Erös, P. Mátyus

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cyclization of tert-anilines with a properly substituted vinyl moiety by the tert-amino effect affords fused pyridines. This type of ring closure reaction of 5-morpholino-4-vinylpyridazinones and a benzene analogue was investigated by differential scanning calorimetry (DSC) measurements. The structure of products was confirmed by spectroscopic and microanalytical methods. The enthalpy values and heats of reactions were obtained from the thermograms by integrating the peak area corresponding to the ring-closure reaction, and by semiempirical (PM3) and DFT (density function theory) calculations, respectively.

Original languageEnglish
Pages (from-to)667-680
Number of pages14
JournalJournal of Molecular Structure: THEOCHEM
Volume666-667
DOIs
Publication statusPublished - Dec 29 2003

Fingerprint

Aniline Compounds
Pyridines
Morpholinos
Cyclization
Differential Scanning Calorimetry
Aniline
Benzene
Pyridine
Probability density function
closures
Differential scanning calorimetry
Enthalpy
Hot Temperature
rings
thermograms
aniline
pyridines
heat measurement
enthalpy
benzene

Keywords

  • Differential scanning calorimetry
  • Pyridopyridazines
  • Tert-amino effect
  • Vinylpyridazines

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Computational Theory and Mathematics
  • Atomic and Molecular Physics, and Optics

Cite this

Thermochemical study on the ring closure reaction of 5-morpholino-4- vinylpyridazinones by tert-amino effect. / Károlyházy, László; Regdon, Géza; Éliás, Olivér; Beke, Gyula; Tábi, T.; Pintye-Hódi, K.; Erös, I.; Mátyus, P.

In: Journal of Molecular Structure: THEOCHEM, Vol. 666-667, 29.12.2003, p. 667-680.

Research output: Contribution to journalArticle

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AU - Károlyházy, László

AU - Regdon, Géza

AU - Éliás, Olivér

AU - Beke, Gyula

AU - Tábi, T.

AU - Pintye-Hódi, K.

AU - Erös, I.

AU - Mátyus, P.

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AB - Cyclization of tert-anilines with a properly substituted vinyl moiety by the tert-amino effect affords fused pyridines. This type of ring closure reaction of 5-morpholino-4-vinylpyridazinones and a benzene analogue was investigated by differential scanning calorimetry (DSC) measurements. The structure of products was confirmed by spectroscopic and microanalytical methods. The enthalpy values and heats of reactions were obtained from the thermograms by integrating the peak area corresponding to the ring-closure reaction, and by semiempirical (PM3) and DFT (density function theory) calculations, respectively.

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