Thermoanalytical studies on complexes of ketoconazole with cyclodextrin derivatives

F. Taneri, T. Güneri, Z. Aigner, O. Berkesi, M. Kata

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Inclusion complexation between cyclodextrin derivatives (hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin) and a very poorly water-soluble antifungal agent, ketoconazole, was studied. Solid products were prepared by physical mixing, kneading and spray-drying methods in four molecular ratios: 2:1, 1:1, 1:2 and 1:3. The possibility of complex formation between the drug and the cyclodextrins was studied by thermal analysis. Supplementary techniques, such as X-ray diffractometry and Fourier transformation-infrared spectroscopy, were also applied to interpret the results of the thermal study of the products.

Original languageEnglish
Pages (from-to)769-777
Number of pages9
JournalJournal of Thermal Analysis and Calorimetry
Volume74
Issue number3
DOIs
Publication statusPublished - 2003

Fingerprint

Ketoconazole
Cyclodextrins
Derivatives
Fourier transformation
products
drying
sprayers
thermal analysis
drugs
Antifungal agents
infrared spectroscopy
inclusions
Spray drying
Antifungal Agents
Complexation
X ray diffraction analysis
Thermoanalysis
water
Infrared spectroscopy
x rays

Keywords

  • FT-IR spectroscopy
  • Hydroxypropyl-β-cyclodextrin
  • Ketoconazole
  • Methyl-β-cyclodextrin
  • Thermal analysis
  • X-ray diffractometry

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Thermoanalytical studies on complexes of ketoconazole with cyclodextrin derivatives. / Taneri, F.; Güneri, T.; Aigner, Z.; Berkesi, O.; Kata, M.

In: Journal of Thermal Analysis and Calorimetry, Vol. 74, No. 3, 2003, p. 769-777.

Research output: Contribution to journalArticle

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