Thermoanalytical studies on complexes of ketoconazole with cyclodextrin derivatives

F. Taneri, T. Güneri, Z. Aigner, O. Berkesi, M. Kata

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Inclusion complexation between cyclodextrin derivatives (hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin) and a very poorly water-soluble antifungal agent, ketoconazole, was studied. Solid products were prepared by physical mixing, kneading and spray-drying methods in four molecular ratios: 2:1, 1:1, 1:2 and 1:3. The possibility of complex formation between the drug and the cyclodextrins was studied by thermal analysis. Supplementary techniques, such as X-ray diffractometry and Fourier transformation-infrared spectroscopy, were also applied to interpret the results of the thermal study of the products.

Original languageEnglish
Pages (from-to)769-777
Number of pages9
JournalJournal of Thermal Analysis and Calorimetry
Volume74
Issue number3
DOIs
Publication statusPublished - Dec 29 2003

Keywords

  • FT-IR spectroscopy
  • Hydroxypropyl-β-cyclodextrin
  • Ketoconazole
  • Methyl-β-cyclodextrin
  • Thermal analysis
  • X-ray diffractometry

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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