Thermoanalytical studies on complexes of furosemide with β-cyclodextrin derivatives

R. M. Amin Kreaz, C. Novák, I. Erös, M. Kata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Solid formulas obtained between furosemide and two β-cyclodextrin derivatives (HP-β-CD and RAMEB) were prepared by different methods and in various ratios (1:1 and 1:2). The inclusion complex formation between the drug and the β-CDs of 1:1 ratio was evaluated by mean of thermal analysis (DSC, TG and EGD). Supplementary techniques, such as X-ray diffraction, were also applied to interpret the results of the thermal study of physically mixed and kneaded products. Both studies demonstrated the formation of inclusion complexes in all samples except the physical mix samples; formation of true inclusion complexes was then possible only when the components were in melted form. The complexation increased the solubility and the rate of dissolution of the drug. RAMEB was found to be a better complexing agent than HP-β-CD; in both ratios it can be selected as a vehicle in furosemide tablet preparations.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalJournal of Thermal Analysis and Calorimetry
Volume55
Issue number1
Publication statusPublished - 1999

Fingerprint

Cyclodextrins
Furosemide
inclusions
Derivatives
drugs
tablets
Complexation
Pharmaceutical Preparations
Thermoanalysis
Tablets
dissolving
vehicles
thermal analysis
Dissolution
solubility
Solubility
X ray diffraction
preparation
products
diffraction

Keywords

  • Furosemide
  • HP-β-CD
  • RAMEB
  • Thermal analysis

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Thermoanalytical studies on complexes of furosemide with β-cyclodextrin derivatives. / Amin Kreaz, R. M.; Novák, C.; Erös, I.; Kata, M.

In: Journal of Thermal Analysis and Calorimetry, Vol. 55, No. 1, 1999, p. 115-122.

Research output: Contribution to journalArticle

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