Patkány myometrium termoanalitikai vizsgálata terhesség alatt

Translated title of the contribution: Thermoanalytical investigation of rat myometrium during gestation

Csík Gábor, Patzai Balázs, G. Falkay, I. Zupkó

Research output: Contribution to journalArticle

Abstract

The aim of our present study was the investigation of rat myometrium by means of differential scanning calorimetry as a function of gestational age. Some additional groups of animals were exposed to adjuvant arthritis as a model for generalized inflammation. In order to find a connection between calorimetrically determined parameters and motor activity isolated organ experiments were performed and spontaneous as well as KCl-stimulated contractility were recorded. Uterine rings from the 5th day of early pregnancy (days 3-6) exhibited a maximum motor activity. A close correlation was revealed between calorimetric enthalpy (ΔH value) and basal and stimulated contractility. The generalized inflammation increased the maximal contractions at all tested stages (non pregnant, days 14 and 21). As gestation progressed AH value increased in control rats but not in animals exposed to inflammation. Our results indicate that calorimetric technique is suitable for functional investigation of pregnancy-induced or disease-related changes of myometrial samples.

Original languageHungarian
Pages (from-to)117-123
Number of pages7
JournalActa Pharmaceutica Hungarica
Volume79
Issue number3
Publication statusPublished - 2009

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Myometrium
Inflammation
Pregnancy
Motor Activity
Experimental Arthritis
Differential Scanning Calorimetry
Gestational Age

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Patkány myometrium termoanalitikai vizsgálata terhesség alatt. / Gábor, Csík; Balázs, Patzai; Falkay, G.; Zupkó, I.

In: Acta Pharmaceutica Hungarica, Vol. 79, No. 3, 2009, p. 117-123.

Research output: Contribution to journalArticle

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