Thermoanalytical, FTIR and X-ray studies of gemfibrozil-cyclodextrin complexes

Z. Aigner, H. B. Hassan, O. Berkesi, M. Kata, I. Erős

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Inclusion complexation between dimethyl-β-cyclodextrin and a very poorly water-soluble serum lipid-regulating agent, gemfibrozil, was studied. Products were prepared by several methods (physical mixing, kneading, spray-drying and ultrasonic treatment) in four different molecular ratios (2:1, 1:1, 1:2 and 1:3). The possibility of complex formation between the drug and the host molecule was studied by thermal analysis. Supplementary techniques, such as Fourier transformation-infrared spectroscopy and X-ray diffractometry, were also applied to interpret the results of thermal study of the products.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalJournal of Thermal Analysis and Calorimetry
Volume81
Issue number2
DOIs
Publication statusPublished - Jul 2005

Keywords

  • DSC
  • Dimethyl-β-cyclodextrin
  • FTIR spectroscopy
  • Gemfibrozil
  • X-ray diffractometry

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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