Thermally reversible gels based on acryloyl-L-proline methyl ester as drug delivery systems

Flavia Martellini, Olga Z. Higa, E. Takács, Agneza Safranj, Masaru Yoshida, Ryoichi Katakai, Mario Carenza

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Thermally reversible hydrogels were synthesized by radiation-induced copolymerization of acryloyl-L-proline methyl ester with hydrophilic or hydrophobic monomers. The swelling behaviour was found to be affected by a proper balance of the latter. In particular, the transition temperature of the different hydrogels shifted to higher or lower values depending on the presence of hydrophilic or hydrophobic moieties in the polymer chain, respectively. Acetaminophen, an analgesic and antipyretic drug, was entrapped into some hydrogels and a wide range of release rates was obtained according to the nature of the comonomers. A novel thermoresponsive hydrogel was also prepared by radiation polymerization of acryloyl-L-proline methyl ester in the presence of 4-acryloyloxy acetanilide, an acrylic derivative of acetaminophen. Again, the swelling curves showed an inverse function of temperature. It was shown that with this hydrogel bearing the drug covalently attached to the polymer backbone, the hydrolysis process was the rate- determining process of the drug release.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalRadiation Physics and Chemistry
Volume55
Issue number2
DOIs
Publication statusPublished - Jun 11 1999

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esters
delivery
drugs
gels
swelling
acetanilide
polymers
copolymerization
radiation
hydrolysis
polymerization
monomers
transition temperature
curves
temperature

ASJC Scopus subject areas

  • Radiation

Cite this

Thermally reversible gels based on acryloyl-L-proline methyl ester as drug delivery systems. / Martellini, Flavia; Higa, Olga Z.; Takács, E.; Safranj, Agneza; Yoshida, Masaru; Katakai, Ryoichi; Carenza, Mario.

In: Radiation Physics and Chemistry, Vol. 55, No. 2, 11.06.1999, p. 185-192.

Research output: Contribution to journalArticle

Martellini, Flavia ; Higa, Olga Z. ; Takács, E. ; Safranj, Agneza ; Yoshida, Masaru ; Katakai, Ryoichi ; Carenza, Mario. / Thermally reversible gels based on acryloyl-L-proline methyl ester as drug delivery systems. In: Radiation Physics and Chemistry. 1999 ; Vol. 55, No. 2. pp. 185-192.
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