Thermal study of ethyl cellulose coating films used for modified release (MR) dosage forms

Géza Regdon, Diána Hegyesi, Klára Pintye-Hódi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of our research was to investigate the effect of the length of the polymer chain and the concentration of triethyl citrate used as a plasticizer on the thermal stability of the film structure in the case of two ethyl cellulose films (EC 10 and EC 45) used for preparing MR dosage forms. The influence of storage time was studied by monitoring the changes in the thermoanalytical parameters and by performing TG-MS examinations. It was found that the decomposition of the plasticizer from the arising film structure is retarded and a more homogeneous sample, therefore a better film can be prepared from EC 45. Mass spectrography performed as a coupled technique also proved that the films stayed stable until approximately 200 °C. Based on the above results, the composition prepared from EC 45 polymer with 5% triethyl citrate as plasticizer is recommended for making MR dosage forms.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalJournal of Thermal Analysis and Calorimetry
Volume108
Issue number1
DOIs
Publication statusPublished - Apr 1 2012

Keywords

  • DSC
  • Ethyl cellulose
  • Free films
  • Glass transition temperature
  • MFT
  • Physical-chemical investigations
  • TG-MS
  • Triethyl citrate

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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