Thermal study of complex formation of triamterene with β-cyclodextrin by spray-drying and co-grinding

J. M. Ginés, M. J. Arias, C. Novák, P. J. Sánchez-Soto, A. Ruiz-Conde, E. Morillo

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7 Citations (Scopus)


The formation of crystalline inclusion complex of triamterene with β-cyclodextrin (β-CD) was studied, evaluating the thermal behaviour and dispersion state of this drug in different types of binary systems. Spray-drying and co-grinding (oscillating mill) mixtures of triameterene with β-CD were prepared in 1:1 molar ratio. The changes of crystalline properties of original (untreated) triamterene, β-CD, and composites obtained by co-grinding and spray-drying were investigated in comparison with those produced in simple physical mixtures. The thermal behaviour of the different samples was investigated using DTA. X-ray diffraction was applied as a complementary technique. The results have been explained by formation of amorphous drug particles on spray-drying samples and co-grinding or alternatively by means of a solid dispersion formation or a combination of these two. A contamination effect by grinding media was also observed as increasing grinding time.

Original languageEnglish
Pages (from-to)659-666
Number of pages8
JournalJournal of thermal analysis
Issue number4
Publication statusPublished - Oct 1 1995


  • DTA
  • X-ray
  • complex formation
  • triamterene
  • β-cyclodextrin

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Engineering(all)

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