Thermal characterization of natural and modified cyclodextrins using TG-MS combined technique

Zsuzsanna Éhen, F. Giordano, J. Sztatisz, L. Jicsinszky, C. Novák

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Thermoanalytical techniques (TG, DSC) are frequently used in the investigation of the thermal properties of cyclodextrins and their inclusion complexes. However, the above techniques do not provide information on the chemical composition of the evolved fragments upon the thermal decomposition. In this study &agr;-, &bgr;- and &ggr;-cyclodextrins and 4 methylated and 3 ethylated &bgr;-CD derivatives were investigated with a TG-MS combined thermoanalytical technique in order to get information about their fragmentation behaviour. By comparison of the TG/DTA curves, a different thermal behaviour was found for each of the native and the chemically modified cyclodextrins. Except for the water loss profiles and the solid-solid phase transformations, the thermal behaviour of the (investigated) native CDs do not show remarkable differences. However, the chemical modification of the native &bgr;-CD resulting in a new compound may change the strength of interactions between host and guest causing differences in the thermal stabilities of the derivatives. The mass spectrometry results supported the observed thermal differences and showed significant alterations in the fragmentation of ethylated and methylated compounds. The investigated natural CDs possess a very similar fragmentation profile, due to the common &agr;-D-glucopyranose building units. In the case of modified CDs characteristic signals of the substituents are present.

Original languageEnglish
Pages (from-to)419-424
Number of pages6
JournalJournal of Thermal Analysis and Calorimetry
Volume80
Issue number2
DOIs
Publication statusPublished - May 2005

Fingerprint

Cyclodextrins
fragmentation
water loss
Derivatives
Chemical modification
profiles
Differential thermal analysis
thermal decomposition
Mass spectrometry
phase transformations
solid phases
chemical composition
thermal analysis
Pyrolysis
Thermodynamic stability
thermal stability
mass spectroscopy
Thermodynamic properties
thermodynamic properties
Phase transitions

Keywords

  • Combined technique
  • Cyclodextrin
  • Mass spectrometry
  • TG-MS
  • Thermal analysis

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Thermal characterization of natural and modified cyclodextrins using TG-MS combined technique. / Éhen, Zsuzsanna; Giordano, F.; Sztatisz, J.; Jicsinszky, L.; Novák, C.

In: Journal of Thermal Analysis and Calorimetry, Vol. 80, No. 2, 05.2005, p. 419-424.

Research output: Contribution to journalArticle

Éhen, Zsuzsanna ; Giordano, F. ; Sztatisz, J. ; Jicsinszky, L. ; Novák, C. / Thermal characterization of natural and modified cyclodextrins using TG-MS combined technique. In: Journal of Thermal Analysis and Calorimetry. 2005 ; Vol. 80, No. 2. pp. 419-424.
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