Thermal characterisation of torasemide using coupled techniques

J. M. Rollinger, Cs Novák, Zs Éhen, K. Marthi

Research output: Contribution to journalArticle

11 Citations (Scopus)


Thermal treatment of torasemide form A resulted in several effects which were divided into five steps. These were investigated and discussed applying TG-MS and TG-FTIR with additional information derived from SEM, hot-stage and FTIR microscopy. The investigated crystal form of torasemide represents a mixed solvate including ethanol and water. Its desolvation, the solid-solid transformation into the anhydrate mod. II and the melting of this anhydrate is elucidated using thermal analysis and microscopic observations (FTIR and hot-stage microscopy). The released and evaporated solvents were determined with coupled techniques. On further heating the structural identification of evolved gases allowed the analysis of the degradation pathway of torasemide up to 340°C.

Original languageEnglish
Pages (from-to)519-526
Number of pages8
JournalJournal of Thermal Analysis and Calorimetry
Issue number2
Publication statusPublished - Sep 4 2003



  • Coupled techniques
  • Desolvation
  • Hot-stage microscopy
  • SEM
  • TG-MS
  • Thermal decomposition
  • Torasemide

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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