Thermal behavior of furosemide

Rita De Cássia Da Silva, Felipe Silva Semaan, Csaba Novák, Eder Tadeu Gomes Cavalheiro

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Data from theoretical, thermal, and spectroscopic methods were compared in order to map a possible mechanism for the thermal decomposition of furosemide, a diuretic compound, in solid state. TG/DTG curves suggested a two-stage decomposition process. The first product of decomposition is water (m/z = 18), released due to a dimerization resulting in the formation of an amide. Then carbon dioxide (m/z = 44), nitroxide (m/z = 30), and 2-methyl-furanyl ion (m/z = 81) are released in the second stage. The chlorine substituted benzene ring, due to the double bond conjugated system, being the last fraction to decompose. Theoretical calculations presented are in agreement with experimental results.

Original languageEnglish
Pages (from-to)1933-1937
Number of pages5
JournalJournal of Thermal Analysis and Calorimetry
Volume111
Issue number3
DOIs
Publication statusPublished - Mar 1 2013

Keywords

  • Decomposition mechanism
  • Furosemide
  • TG-MS combined technique

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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    De Cássia Da Silva, R., Semaan, F. S., Novák, C., & Cavalheiro, E. T. G. (2013). Thermal behavior of furosemide. Journal of Thermal Analysis and Calorimetry, 111(3), 1933-1937. https://doi.org/10.1007/s10973-011-2058-8