Thermal analysis and compatibility studies of prednicarbate with excipients used in semi solid pharmaceutical form

H. Salvio Neto, C. Novák, J. R. Matos

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Differential Scanning Calorimetry (DSC), thermogravimetry/derivative thermogravimetry (TG/DTG) and infrared spectroscopy (IR) techniques were used to investigate the compatibility between prednicarbate and several excipients commonly used in semi solid pharmaceutical form. The thermoanalytical studies of 1:1 (m/m) drug/excipient physical mixtures showed that the beginning of the first thermal decomposition stage of the prednicarbate (T onset value) was decreased in the presence of stearyl alcohol and glyceryl stearate compared to the drug alone. For the binary mixture of drug/sodium pirrolidone carboxilate the first thermal decomposition stage was not changed, however the DTG peak temperature (T peak DTG) decreased. The comparison of the IR spectra of the drug, the physical mixtures and of the thermally treated samples confirmed the thermal decomposition of prednicarbate. By the comparison of the thermal profiles of 1:1 prednicarbate:excipients mixtures (methylparaben, propylparaben, carbomer 940, acrylate crosspolymer, lactic acid, light liquid paraffin, isopropyl palmitate, myristyl lactate and cetyl alcohol) no interaction was observed.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalJournal of Thermal Analysis and Calorimetry
Volume97
Issue number1
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Excipients
Thermoanalysis
compatibility
thermal analysis
drugs
thermal decomposition
thermogravimetry
Pyrolysis
Pharmaceutical Preparations
carbopol 940
alcohols
infrared spectroscopy
Thermogravimetric analysis
Infrared spectroscopy
stearates
lactates
lactic acid
paraffins
Stearates
acrylates

Keywords

  • Compatibility study
  • IR spectroscopy
  • Prednicarbate
  • Thermal analysis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

Cite this

Thermal analysis and compatibility studies of prednicarbate with excipients used in semi solid pharmaceutical form. / Neto, H. Salvio; Novák, C.; Matos, J. R.

In: Journal of Thermal Analysis and Calorimetry, Vol. 97, No. 1, 07.2009, p. 367-374.

Research output: Contribution to journalArticle

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